79645-27-5

• 常用中文名：硫酸妥布霉素
• 常用英文名：Dicon
• CAS号：79645-27-5
• 分子式：C₁₈H₃₉N₅O₁₃S
• 分子量：565.593
• 相关类别： 原料药 抗生素类药物 氨基糖苷类药
• 发布时间：2018-09-27 22:50:45
• 更新时间：2024-01-03 23:10:04
• Tobramycin Sulfate is a broad-spectrum antibiotic. It is effective against gram-negative bacteria, and especially potent against the Pseudomonas species.

名称

• 中文名: 硫酸妥布霉素
• 英文名: Tobramycin sulphate
• 中文别名: 硫酸托普霉素
• 英文别名: -3,5-diol sulfate (salt); -3,5-diolsulfat(salt); (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminométhyl)-5-hydroxytétrahydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,5-diol sulfate (salt); Tobrasix; (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminométhyl)-5-hydroxytétrahydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxyméthyl)tétrahydro-2H-pyran; (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxytetrahydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol sulfate (salt); Tobra Gobens; Tomycin; EINECS 256-499-2; α-D-Glucopyranoside, (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-, sulfate (1:1) (salt); (1S,2S,3R,4S,6R)-4,6-Diamino-3-[(2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside sulfate (salt); Trazil; Dicon; Tobramycin sulfate; (1S,2S,3R,4S,6R)-4,6-Diamino-3-[(2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside sulfate (1:1); Dartobcin; Tobryne; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxytetrahydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran; Tobracin; MFCD00133864; Nebcine; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxytetrahydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diolsulfat(salt); Obracin; Tobraneg

物化性质

• 沸点: 775.4ºC at 760 mmHg
• 分子式: C₁₈H₃₉N₅O₁₃S
• 分子量: 565.593
• 闪点: 422.8ºC
• 精确质量: 565.226501
• PSA: 351.15000
• 储存条件: 2-8°C

MSDS

Section 1. Chemical Product and Company Identification Tobramycin Sulfate Common Name/ Trade Name Tobramycin Sulfate Section 3. Hazards Identification Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Acute Health Effects CARCINOGENIC EFFECTS: Not available. Potential Chronic Health MUTAGENIC EFFECTS: Not available. Effects TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, ears. Repeated or prolonged exposure to the substance can produce target organs damage. Section 4. First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least Eye Contact 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Skin Contact Cold water may be used. Not available. Serious Skin Contact If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get Inhalation medical attention. Not available. Serious Inhalation Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an Ingestion unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Not available. Serious Ingestion Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Not available. Flammable Limits These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Not available. Special Remarks on Fire Hazards Not available. Special Remarks on Explosion Hazards Tobramycin Sulfate Section 6. Accidental Release Measures Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading Small Spill water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on Large Spill the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not Precautions ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F). Storage Refrigerate. Section 8. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below Engineering Controls recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE of a Large Spill handling this product. Not available. Exposure Limits Section 9. Physical and Chemical Properties Solid. (crystalline powder)Not available. Physical state andO dor appearance Not available. Taste 467.51 g/mole Molecular Weight White. Color Not available. pH (1% soln/water) Not available. Boiling Point 549°C (1020.2°F) Melting Point Not available. Critical Temperature Not available. Specific Gravity Not applicable. Vapor Pressure Not available. Vapor Density Not available. Volatility Not available. Odor Threshold Not available. Water/Oil Dist. Coeff. Not available. Ionicity (in Water) See solubility in water. Dispersion Properties Easily soluble in cold water. Solubility Tobramycin Sulfate Section 10. Stability and Reactivity Data The product is stable. Stability Not available. Instability Temperature Conditions of Instability Excess heat, incompatible materials Incompatibility with various Reactive with oxidizing agents, acids. substances Not available. Corrosivity Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity Will not occur. Polymerization Section 11. Toxicological Information Inhalation. Ingestion. Routes of Entry Acute oral toxicity (LD50): 10500 mg/kg [Mouse]. Toxicity to Animals Chronic Effects on Humans May cause damage to the following organs: kidneys, ears. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Not available. Special Remarks on Toxicity to Animals May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data. Special Remarks on Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause nausea, vomiting, increased thirst, loss of appetite. May affect behavior/central nervous system/nervous system (wakefulness, hallucinations, convulsions, muscle twitching, numbness, seizures, tingling, dizziness, unsteadiness, clumsiness, headache), respiration (dyspnea). May also cause skin itching, redness, rash, or swelling. Chronic Potential Health Effects: Ingestion: Prololnged or repeated ingestion may cause weight loss, affect kidneys (acute renal failure, acute tubular necrosis), endocrine system (adrenal gland), ears (change in cochlear structure or function, auditory ototoxicity (any hearing loss, high-pitched ringing or buzzing or feeling of fullness in ears), vestibular ototoxicity (clumsiness ,dizziness ,nausea, vomiting, unsteadiness)), and have symptoms similar to acute ingestion. Section 12. Ecological Information Not available. Ecotoxicity Not available. BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Toxicity of the Products of Biodegradation Not available. Special Remarks on the Products of Biodegradation Tobramycin Sulfate Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information Not a DOT controlled material (United States). DO T Cl assi fi cati on Not applicable. Identification Not applicable. Special Provisions for Transport DO T (Pi ctograms) Section 15. Other Regulatory Information and Pictograms California prop. 65: This product contains the following ingredients for which the State of California has found to Federal and State cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Tobramycin Regulations Sulfate California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Tobramycin Sulfate California prop. 65: This product contains the following ingredients for which the State of California has found to California cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Tobramycin Sulfate OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications This product is not classified according Not applicable. DSCL (EEC) to the EU regulations. HMIS (U.S.A.)Health Hazard1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) Tobramycin Sulfate TDG(Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): T,Xn
• 风险声明 (欧洲): 61-20/21/22
• 安全声明 (欧洲): 53-22-36/37/39-45-3/7/9
• WGK德国: 3
• RTECS号: WK2110000