843663-66-1

• 常用中文名：贝达喹啉
• 常用英文名：Bedaquiline
• CAS号：843663-66-1
• 分子式：C₃₂H₃₁BrN₂O₂
• 分子量：555.50
• 相关类别： 原料药 人工合成抗感染类药 抗结核麻风分支杆菌类药
• 发布时间：2018-03-30 08:00:00
• 更新时间：2026-07-02 15:20:01
• Bedaquiline是一种二芳基喹啉抗生素,可抑制分枝杆菌ATP合成酶。

名称

• 中文名: 6-溴-alpha-[2-(二甲基氨基)乙基]-2-甲氧基-alpha-1-萘基-beta-苯基-3-喹啉乙醇
• 英文名: tmc-207
• 中文别名: 氘6-贝达喹啉; 贝大喹啉; 6-溴-ALPHA-[2-(二甲基氨基)乙基]-2-甲氧基-ALPHA-1-萘基-BETA-苯基-3-喹啉乙醇; 贝达喹啉BEDAQUILINE; 贝达奎林; 6-溴-ALPHA-[2-(二甲基氨基)乙基]-2-甲氧基-ALPHA-1-萘基-BETA-苯基-3-喹啉乙醇 贝达喹啉; (1R,2S)-1-(6-溴-2-甲氧基喹啉-3-基)-4-(二甲基氨基)-2-(萘-1-基)-1-苯基丁-2-醇; 贝达喹啉单体; 乐伐替尼中间体2; (1R,2S)-1-(6-溴-2-甲氧基喹唑-3-基)-4-(二甲基氨基)-2-(萘-1-基)-1-苯基丁-2-醇; 富马酸贝达喹啉相关杂质; 贝达喹啉 D6; 贝达喹啉,10 MM DMSO 溶液; (ΑS,ΒR)-贝达喹啉; 贝达喹林; TMC-207(非正确对映体)
• 英文别名: Bedaquinoline; JAK2-IN-11; (αS,βR)-Bedaquiline; (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol; Bedaquline Fumate; BedaquilineQ: What is Bedaquiline Q: What is the CAS Number of Bedaquiline Q: What is the storage condition of Bedaquiline Q: What e the applications of Bedaquiline; Bedaguiline; (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol; methyl 6-azanyl-2-benzamido-hexanoate hydrochloride; TMC-207 //BP; methyl (2S)-6-amino-2-benzamidohexanoate; bedaquinline; (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol; (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S); 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol; Bedaquiline D6; BEDAQUILINE;TMC207;R207910;TMC 207;R 207910;TMC-207;R-207910; Bedaquiline D6Q: What is Bedaquiline D6 Q: What is the CAS Number of Bedaquiline D6 Q: What is the storage condition of Bedaquiline D6 Q: What e the applications of Bedaquiline D6; (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol; (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)-(1-naphthyl)-1-phenylbutan-2-ol; TMC-207; BZ-LYS-OME HCL; Bedaquiline, 10 mM in DMSO; 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphas,bet; 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol; TMC-207(Bedaquiline); (alphaS,bet-Bedaquiline; Sirturo; BEDAQUILINE (TMC207, R207910); 6-amino-2-benzamidohexanoic acid methyl ester hydrochloride; 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR); D6-Bedaquiline; Bedaquiline (TMC-207); (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl ((R)-H8-TolBINAP); TMC207; (1R,2S)-1-(6-BroMo-2-Methoxyquinolin-3-yl)-4-(diMethylaMino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 702.7±60.0 °C at 760 mmHg
• 分子式: C₃₂H₃₁BrN₂O₂
• 分子量: 555.50
• 闪点: 378.8±32.9 °C
• PSA: 36.36000
• LogP: 7.59
• 外观性状: 粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.666
• 储存条件: -20℃

生物活性

• 描述: Bedaquiline是一种二芳基喹啉抗生素,可抑制分枝杆菌ATP合成酶。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点:

  mycobacterial ATP synthase[1]

• 体外研究: Bedaquiline抑制TDR结核分枝杆菌菌株的生长,MIC值范围为0.125至0.5 mg/L [1]。在缓慢生长的分枝杆菌(SGM)中,对苯二酚对鸟分枝杆菌表现出最高的活性,MIC50和MIC90值分别为0.03和16mg/L.在快速生长的分枝杆菌(RGM)中,脓肿分枝杆菌亚种。脓肿(M. abscessus)和脓肿分枝杆菌亚种massiliense(M。massiliense)似乎比偶发分枝杆菌更容易对bedaquiline敏感,两种物种的MIC50和MIC90值分别为0.13和> 16 mg/L. Bedaquiline也显示出对NTM物种的适度体外活性[2]。 Bedaquiline具有优异的抗结核分枝杆菌的体外活性,包括多药耐药的结核分枝杆菌[3]。
• 参考文献:

  [1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.

  [2]. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).

  [3]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.

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