62978-52-3

• 常用中文名：美法仑甲酯盐酸盐
• 常用英文名：methyl 2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate
• CAS号：62978-52-3
• 分子式：C₁₄H₂₀Cl₂N₂O₂
• 分子量：319.22700
• 发布时间：2017-07-19 20:46:41
• 更新时间：2026-07-09 16:51:18

名称

• 中文名: 美法仑甲酯盐酸盐
• 英文名: methyl 2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate
• 中文别名: 美法仑杂质H HCL; (S)-2-氨基-3-(4-(双(2-氯乙基)氨基)苯基)丙酸甲酯盐酸盐 (美法仑杂质); 美法仑杂质H盐酸盐(美法仑甲酯盐酸盐); 美法仑杂质H HCL(美法仑甲酯HCL); 美法仑杂质H 盐酸盐; 美法仑杂质H; 美法仑杂质8; 美法仑杂质8(美法仑杂质H)
• 英文别名: Melphalan Impurity H HCl; Melphalan Methyl Ester HCl; Methyl 4-[bis(2-chloroethyl)amino]-L-phenylalaninate hydrochloride (1:1); Melphalan lmpurity H; Melphalan Impurity H HCl (Melphalan Methyl Ester HCl); melphalan methyl ester hydrochloride salt; Methyl (S)-2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate Hydrochloride; melphalan methylester hydrochloride; FHKHNGPONDWS-ZOWNYOTGSA-N; Melphalan Impurity 8（Melphalan Impurity H）; Melphalan Impurity 8; Melphalan lmpurity 8; Melphalan Impurity-H (Methyl Ester HCl salt); (S)-Methyl 2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoate hydrochloride (Melphalan Impurity)

物化性质

• 密度: 1.244g/cm3
• 沸点: 437.6ºC at 760 mmHg
• 分子式: C₁₄H₂₀Cl₂N₂O₂
• 分子量: 319.22700
• 闪点: 218.5ºC
• 精确质量: 318.09000
• PSA: 55.56000
• LogP: 2.71370
• 折射率: 1.565

合成路线

1217651-06-3 ~% 62978-52-3

文献：GURJAR, MUKUND KESHAV; Tripathy, Narendra Kumar; Kotharkar, Sandeep Anilrao; Patil, Pradip Nana; Mehta, Samit Satish Patent: US2012/116117 A1, 2012 ; Location in patent: Page/Page column 2 ;

67-56-1 148-82-3 ~56% 62978-52-3

文献：Hsieh, Kun-hwa; Marshall, Garland R. Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1304 - 1310

148-82-3 77-76-9 ~% 62978-52-3

文献：Weerapreeyakul, Natthida; Visser, Petra; Brummelhuis, Mathijn; Gharat, Laxmikant; Chikhale, Prashant J. Medicinal Chemistry Research, 2000 , vol. 10, # 3 p. 148 - 163

上下游产品

上游产品  4
1217651-06-3 67-56-1 148-82-3 77-76-9
下游产品  1
148-82-3