77074-42-1

• 常用中文名：6α-甲基泼尼松龙17-半琥珀酸酯
• 常用英文名：methylprednisolone 17-hemisuccinate
• CAS号：77074-42-1
• 分子式：C₂₆H₃₄O₈
• 分子量：474.54300
• 发布时间：2016-05-24 05:32:07
• 更新时间：2026-06-30 19:13:16

名称

• 中文名: 6α-甲基泼尼松龙17-半琥珀酸酯
• 英文名: 4-[[(6S,8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]oxy]-4-oxobutanoic acid
• 中文别名: 甲泼尼龙杂质B; 甲基泼尼松杂质17; 甲基强的松龙琥珀酸氢酯杂质B(甲基强的松龙17琥珀酸氢酯); 甲泼尼龙-17-琥珀酸酯; 琥珀酸甲泼尼龙杂质B; 4-((((6S,8S,9S,10R,11S,13S,14S,17R)-11-羟基-17-(2-羟基乙酰基)-6,10,13-三甲基-3-氧代-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊基[A]菲-17-基)氧基)-4-氧代丁酸 (甲泼尼龙杂质); 甲基泼尼卡酯龙琥珀酸氢杂质B; 泼尼松龙杂质32; 甲基强的松龙琥珀酸氢盐杂质B; 甲泼尼龙琥珀酸氢杂质B; 甲泼尼龙杂质02; 甲泼尼龙杂质1; 甲泼尼龙琥珀酸酯杂质B; 琥珀酸氢泼尼松龙杂质; 6Α-甲基泼尼松龙17 - 半琥珀酸酯; 6Α-甲基泼尼松龙 17-琥珀酸酯; 甲基泼尼松琥珀酸氢杂质B(甲基泼尼松龙半琥珀酸相关化合物B,甲基泼尼龙17琥珀酸氢); 甲基泼尼松龙琥珀酸氢杂质B; 甲泼尼龙17-琥珀酸氢
• 英文别名: 4-(((6S,8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid (Methylprednisolone Hydrogen Succinate Impurity); Methylprednisolone Hydrogen Succinate Impurity B (Methylprednisolone 17-Hydrogen Succinate); Methylprednisolone Hydrogen Succinate Impurity B (Methylprednisolone Hemisuccinate Related Compound B, Methylprednisolone 17-Hydrogen Succinate); methylprednisolone impurity 02; Methylprednisolone 17-Hydrogen Succinate (Methylprednisolone Hydrogen Succinate Impurity B); Pregna-1,4-diene-3,20-dione, 17-(3-cboxy-1-oxopropoxy)-11,21-dihydroxy-6-methyl-, (6α,11β); 17,21-Dihydroxy-6|A-methylpregna-1,4-diene-3,11,20-trione 21-Acetate; Methylprednisolone 17-Hydrogen Succinate; Methylprednisolone Hemisuccinate RC B; 4-(((6S,8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid; 6a-Methyl Prednisolone 17-Hemisuccinate; Pregna-1,4-diene-3,20-dione,17-(3-cboxy-1-oxopropoxy)-11,21-dihydroxy-6-methyl-, (6a,11b)- (9CI); Methylprednisolone Hydrogen Succinate Impurity B; (6α,11β)-17-(3-Cboxy-1-oxopropoxy)-11,21-dihydroxy-6-Methylpregna- 1,4-diene-3,20-dione; 6alpha-Methylprednisone 21-Acetate; Methylprednisolone Succinate impurity B; 6α-Methyl Prednisolone 17-Hemisuccinate; 6|A-Methyl Prednisone 21-Acetate

物化性质

• 密度: 1.33g/cm3
• 沸点: 679.6ºC at 760 mmHg
• 分子式: C₂₆H₃₄O₈
• 分子量: 474.54300
• 闪点: 226.9ºC
• 精确质量: 474.22500
• PSA: 138.20000
• LogP: 2.21930
• 折射率: 1.593

合成路线

2921-57-5 ~% 77074-42-1

文献：Anderson; Conradi; Johnson Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 4 p. 448 - 454

2921-57-5 ~% 83-43-2 77074-42-1

文献：Anderson; Conradi; Lambert Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 5 p. 604 - 610

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