2921-57-5

• 常用中文名：甲基泼尼松龙琥珀酸酯
• 常用英文名：Methylprednisolone succinate
• CAS号：2921-57-5
• 分子式：C₂₆H₃₄O₈
• 分子量：474.543
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-09-13 15:54:24
• 更新时间：2026-07-07 07:47:00
• Methylprednisolone succinate 是一种合成的糖皮质激素,被广泛用作抗炎剂。

名称

• 中文名: 甲基泼尼松龙琥珀酸酯
• 英文名: 4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
• 中文别名: 甲基泼尼松龙琥珀酸酯/用于性能测试/A1A; 甲基泼尼松杂质15; 6Α-甲基强的松龙21-半琥珀酸酯; METHYLPREDNISOLONE HEMISUCCINATE|||METHYLPREDNISOLONE HYDROGEN SUCCINATE|||甲基泼尼松龙琥珀酸酯; 琥珀酸钾泼尼龙; 甲级泼尼松琥珀醋酸酯; 甲基泼尼松龙琥珀酸酯,10 MM DMSO 溶液; 甲泼尼龙琥珀酸酯; 甲基泼尼松龙琥珀酸; 甲泼尼龙杂质22; 琥珀酸甲泼尼龙; 半琥珀酸甲泼尼龙; 甲基强的松龙21-半琥珀酸酯; 甲基泼尼松龙半琥珀酸酯; 甲基泼尼松21半琥珀酸(甲基泼尼松龙琥珀酸氢盐); 甲基强的松龙琥珀酸酯; 甲基泼尼松龙琥珀酸酯 2-5; 泼尼松龙杂质31; 甲泼尼松杂质15; 甲泼尼龙琥珀氢峰鉴别 标准品; 甲泼尼龙琥珀氢性能测试 标准品; 泼尼松龙琥珀酸酯; 甲基泼尼松龙琥珀酸酯/甲基泼尼松龙琥珀酸/甲级泼尼松琥珀醋酸酯/泼尼松龙琥珀酸酯; 甲泼尼龙琥珀氢 标准品
• 英文别名: methylprednisolone 21-hemisuccinate; METHYLPREDNISOLONE HEMISNCCINATE; 6A-METHYLPREDNISOLONEHEMISUCCINATE; pregna-1,4-diene-3,20-dione,21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxy-6-meth; 11β,17,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate); Pregna-1,4-diene-3,20-dione, 21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β); 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate); METHYLPREDNISOLONE HEMISUCCINATE; 6α-Methylprednisolone Hemisuccinate; 1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE; Methylprednisolone hemisuccinate; Methylprednisolone sucsinate; Methylprednisolone hydrogen succinate for peak identification CRS; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate; Methylprednisolone succinate, 10 mM in DMSO; Methylprednisolone 21-Hemisuccinate (Methylprednisolone Hydrogen Succinate); (6-alpha,11-beta)-yl; 21-(3-Cboxy-1-oxopropoxy)-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione; MFCD00271782; 4-{[(6α,11β)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoic acid; methylprednisolone hemisuccinate esters; METHYLPRENISOLONE HEMISUCCINATE; Methylprednisolone hydrogen succinateQ: What is Methylprednisolone hydrogen succinate Q: What is the CAS Number of Methylprednisolone hydrogen succinate Q: What e the applications of Methylprednisolone hydrogen succinate; Methylprednisolone hydrogen hemisuccinate; Pregna-1,4-diene-3,20-dione,21-(3-cboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6a,11b); Methylprednisolone hemisuccinate Powder; 6.alpha.-Methylprednisolone 21-hemisuccinate; 1, 4-PREGNADIEN-6α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-HEMISUCCINATE; drogensuccinate); Solumedrol; UNII-5GMR90S4KN; METHYLPREDNISOLONE SODIUM SUCCINATE; 11b,17,21-Trihydroxy-6a-methylpregna-1,4-diene-3,20-dione 21-(Hydrogen Succinate); Methylprednisolone hydrogen succinate for performance test CRS; 6-alpha-Methyl Isomer of Methylhydrocortisone 21-Hydrogen Succinate; Methylprednisolone Hemisuccinate BP; Methylprednisolone, Powder; Methylprednisolone 21-Hemisuccinate; 6a-Methylprednisolone 21-Hemisuccinate; 4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-suc; methylprednisolonesuccinate; Methylprednisolone Succinate RS; METHYLPREDNISOLONE 21-HEMISUCCINATE (6-ALPHA-METHYL ISOMER OF METHYLHYDROCORTISONE 21-HYDROGEN SUCCINATE); Methylprednisolone hydrogen succinate CRS; 4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hy; 6 ALPHA-METHYLPREDNISOLONE HEMISUCCINATE; MEGHYLPREDNISOLONE HEMISUCCINATE; METHYLPREDINISOLONE HEMISUCCINATE; 6a- methyl prednisolone acetate half Kohaku; Urbason-Soluble; Methylprednisolone hydrogen succinate for peak identification; Methylprednisolone Impurity 15; Butanedioic acid, mono[(6α,11β)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl] ester; 21-(3-Cboxy-1-oxopropoxy)-11β,17-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione; Methylprednisolone sodium hemisuccinate; 6-methylprednisolone-21-hemisuccinate; Methylprednisolone hydrogen succinate; 6α-Methylprednisolone 21-HeMisuccinate; 6-methylprednisolonehemisuccinate; Methylprednisolone Hemisuccinate //BP; EINECS 220-863-9; 11β,17α-Dihydroxy-3,20-dioxo-6α-methylpregna-1,4-diene-21-ol 21-(4-hydroxy-4-oxobutyrate); METHYLPREDNISOLONEHEMISUCCINATE; methylprednisolone succinate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 689.6±55.0 °C at 760 mmHg
• 分子式: C₂₆H₃₄O₈
• 分子量: 474.543
• 闪点: 230.7±25.0 °C
• 精确质量: 474.225372
• PSA: 138.20000
• LogP: 2.69
• 蒸汽压: 0.0±4.9 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 2-8℃

生物活性

• 描述: Methylprednisolone succinate 是一种合成的糖皮质激素,被广泛用作抗炎剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 靶点:

  glucocorticoid receptor[1]

• 参考文献:

  [1]. Marchant A, et al. Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) productionduring murine endotoxaemia. Clin Exp Immunol. 1996 Oct;106(1):91-6.

  [2]. Diem R, et al. Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci. 2003 Aug 6;23(18):6993-7000.

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2942000000

合成路线

77074-42-1 ~% 83-43-2 2921-57-5

文献：Anderson; Conradi; Lambert Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 5 p. 604 - 610

77074-42-1 ~% 2921-57-5

文献：Anderson; Taphouse Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 2 p. 181 - 186

海关

海关编码	2942000000