197142-36-2

• 常用中文名：(1S,3S,5S)-2-(叔丁氧基羰基)-2-氮杂二环[3.1.0]己烷-3-羧酸
• 常用英文名：(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
• CAS号：197142-36-2
• 分子式：C₁₁H₁₇NO₄
• 分子量：227.25700
• 发布时间：2016-07-16 14:01:03
• 更新时间：2026-10-30 17:06:24

名称

• 中文名: (1S,3S,5S)-2-(叔丁氧基羰基)-2-氮杂二环[3.1.0]己烷-3-羧酸
• 英文名: (3S)-2-[(2-methylpropan-2-yl)oxycarbonyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
• 中文别名: (1S,3S,5S)-2-BOC-2-氮杂双环[3.1.0]己烷-3-甲酸; (1S,3S,5S)-2-BOC-2-氮杂双环[3.1.0]己烷-3-羧酸; (1S,3S,5S)-2-(叔-丁氧羰基)-2-氮杂二环[3.1.0]己烷-3-羧酸
• 英文别名: N-Boc-L-cis-4,5-methanoproline; Azabicyclo BOC acid impurity; (1S,3S,5S)-2-Boc-2-aza-bicyclo[3.1.0]hexane-3-dicboxylic acid; 2-Azabicyclo[3.1.0]hexane-2,3-dicboxylic acid, 2-(1,1-dimethylethyl) ester, (1S,3S,5S); (1S,3S,5S)-2-(TERT-BUTOXYCBONYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CBOXYLIC ACID; (4S,5S)-metano-N-Boc-L-proline; (1S,3S,5S)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester; 2-azabicyclo[3.1.0]hexane-3-cboxylic acid; (3S)-2-[(2-methylpropan-2-yl)oxycbonyl]-2-azabicyclo[3.1.0]hexane-3-cboxylic acid; (1S,3S,5S)-2-[(2-methylpropan-2-yl)oxycbonyl]-2-azabicyclo[3.1.0]hexane-3-cboxylic acid; (1S,3S,5S)-N2-BOC-2-AZABICYCLO[3.1.0]HEXANE-3-CBOXYLIC ACID; s-BOC-4,5-methanoproline; (1s,3s,5s)-2-boc-2-azabicyclo[3.1.0]hexane-3-cboxylic acid

物化性质

• 沸点: 355.9±25.0 °C at 760 mmHg (lit.)
• 分子式: C₁₁H₁₇NO₄
• 分子量: 227.25700
• 精确质量: 227.11600
• PSA: 66.84000
• LogP: 1.40680
• 外观性状: 白色至黄色固体
• 储存条件: 2-8°C，干燥

安全

• 危害码 (欧洲): Xi

合成路线

214193-11-0 ~97% 197142-36-2

文献：ALANTOS PHARMACEUTICALS, INC. Patent: WO2006/116157 A2, 2006 ; Location in patent: Page/Page column 114-115 ; WO 2006/116157 A2

1313751-21-1 ~99% 197142-36-2

文献：BRISTOL-MYERS SQUIBB COMPANY; LOPEZ, Omar D.; ST. LAURENT, Denis R.; GOODRICH, Jason; ROMINE, Jeffrey Lee; SERRANO-WU, Michael; YANG, Fukang; KAKARLA, Ramesh; YANG, Xuejie; QIU, Yuping; SNYDER, Lawrence B. Patent: WO2011/82077 A1, 2011 ; Location in patent: Page/Page column 299 ;

7647-01-0 ~82% 197142-36-2

文献：BRISTOL-MYERS SQUIBB COMPANY Patent: WO2004/52850 A2, 2004 ; Location in patent: Page 77 ; WO 2004/052850 A2

138629-30-8 ~% 197142-36-2

文献：Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

361440-67-7 ~% 197142-36-2

文献：BRISTOL-MYERS SQUIBB COMPANY; LOPEZ, Omar D.; ST. LAURENT, Denis R.; GOODRICH, Jason; ROMINE, Jeffrey Lee; SERRANO-WU, Michael; YANG, Fukang; KAKARLA, Ramesh; YANG, Xuejie; QIU, Yuping; SNYDER, Lawrence B. Patent: WO2011/82077 A1, 2011 ;

上下游产品

上游产品  4
214193-11-0 7647-01-0 138629-30-8 361440-67-7
下游产品  1
361440-67-7