73671-86-0

• 常用中文名：17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one
• 常用英文名：17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one
• CAS号：73671-86-0
• 分子式：C₂₄H₄₀N₂O₂
• 分子量：388.59
• 相关类别： 研究领域 心血管疾病
• 发布时间：2017-10-18 19:24:36
• 更新时间：2024-01-09 19:38:45
• DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。

名称

• 英文名: (7S,11aR)-N,N-Diethyl-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-ind eno[5,4-f]quinoline-7-carboxamide

物化性质

• 密度: 1.051g/cm3
• 沸点: 528.3ºC at 760 mmHg
• 分子式: C₂₄H₄₀N₂O₂
• 分子量: 388.59
• 闪点: 209.8ºC
• 精确质量: 388.30900
• PSA: 40.62000
• LogP: 4.27230
• 折射率: 1.519

生物活性

• 描述: DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rodricks JV, et al. DMAA as a dietary ingredient. JAMA Intern Med. 2013 Apr 8;173(7):594-5.

  [2]. Richard J Bloomer, et al. 1,3-Dimethylamylamine (DMAA): A Brief History and Review of Anecdotal and Laboratory Findings. J Altern Complement Integr Med. 2018 Dec 28.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CL5200000 CHEMICAL NAME : 5-alpha-4-Azaandrostane-17-beta-carboxamide, N,N-diethyl-4-methyl-3-oxo- CAS REGISTRY NUMBER : 73671-86-0 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C24-H40-N2-O2 MOLECULAR WEIGHT : 388.66 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2100 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 700 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 135 mg/kg SEX/DURATION : female 13-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982

合成路线

73671-98-4 ~96% 73671-86-0 92472-68-9 92472-89-4

文献：Rasmusson, Gary H.; Reynolds, Glenn F.; Utne, Torleif; Jobson, Ronald B.; Primka, Raymond L.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1690 - 1701

73671-98-4 7631-86-9 ~% 73671-86-0

文献：Merck and Co., Inc. Patent: US4220775 A1, 1980 ;

76763-16-1 ~% 73671-86-0

文献：Rasmusson, Gary H.; Reynolds, Glenn F.; Utne, Torleif; Jobson, Ronald B.; Primka, Raymond L.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1690 - 1701

76763-18-3 109-89-7 ~% 73671-86-0

文献：Rasmusson, Gary H.; Reynolds, Glenn F.; Utne, Torleif; Jobson, Ronald B.; Primka, Raymond L.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1690 - 1701

92472-63-4 74-89-5 ~% 73671-86-0 92472-64-5

文献：Rasmusson, Gary H.; Reynolds, Glenn F.; Utne, Torleif; Jobson, Ronald B.; Primka, Raymond L.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1690 - 1701