17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one

• 常用名: 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one
• 英文名: 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one
• CAS号: 73671-86-0
• 分子量: 388.59
• 密度: 1.051g/cm3
• 沸点: 528.3ºC at 760 mmHg
• 分子式: C₂₄H₄₀N₂O₂
• 熔点: N/A
• 闪点: 209.8ºC

用途

DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。

名称

• 英文名: (7S,11aR)-N,N-Diethyl-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-ind eno[5,4-f]quinoline-7-carboxamide

生物活性

• 描述: DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rodricks JV, et al. DMAA as a dietary ingredient. JAMA Intern Med. 2013 Apr 8;173(7):594-5.

  [2]. Richard J Bloomer, et al. 1,3-Dimethylamylamine (DMAA): A Brief History and Review of Anecdotal and Laboratory Findings. J Altern Complement Integr Med. 2018 Dec 28.

物理化学性质

• 密度: 1.051g/cm3
• 沸点: 528.3ºC at 760 mmHg
• 分子式: C₂₄H₄₀N₂O₂
• 分子量: 388.59
• 闪点: 209.8ºC
• 精确质量: 388.30900
• PSA: 40.62000
• LogP: 4.27230
• InChIKey: GNWBLLYJQXKPIP-ZOGIJGBBSA-N
• SMILES: CCN(CC)C(=O)C1CCC2C3CCC4N(C)C(=O)CCC4(C)C3CCC12C
• 折射率: 1.519

毒性和生态

靶点实验

查看更多实验

实验名称：In vitro inhibitory activity against human type 2 5-alpha reductase 来源：ChEMBL 靶标：3-oxo-5-alpha-steroid 4-dehydrogenase 2 External Id：CHEMBL810001

实验名称：In vitro inhibitory activity against human type 1 5-alpha reductase 来源：ChEMBL 靶标：3-oxo-5-alpha-steroid 4-dehydrogenase 1 External Id：CHEMBL816494

实验名称：Ratio of IC50 to that of 10x compound against Steroid 5-alpha-reductase 来源：ChEMBL 靶标：3-oxo-5-alpha-steroid 4-dehydrogenase 2 External Id：CHEMBL814228

实验名称：In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductase 来源：ChEMBL 靶标：3-oxo-5-alpha-steroid 4-dehydrogenase 1 External Id：CHEMBL813360

实验名称：Comparative activity against Testosterone 5 alpha-Reductase evaluated by setting Ki o... 来源：ChEMBL 靶标：N/A External Id：CHEMBL809264

实验名称：In vitro antagonist activity against rat prostatic androgen receptor (AR) 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL652259

实验名称：In vitro inhibitory activity against human adrenal 3-beta hydroxy-delta 5-teroid isom... 来源：ChEMBL 靶标：N/A External Id：CHEMBL615557

实验名称：In vitro inhibitory activity against rat prostatic 5-alpha-reductase (150 ng/tube) 来源：ChEMBL 靶标：3-oxo-5-alpha-steroid 4-dehydrogenase 1 External Id：CHEMBL816486

实验名称：Ratio of compound IC50 to (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N,N-diethyl-1,4a,6a-trimethyl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3074802

实验名称：Ratio of compound pIC50 to (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N,N-diethyl-1,4a,6a-trimethy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3074801

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