1229194-11-9

• 常用中文名：伊多塞班对甲苯磺酸盐一水合物
• 常用英文名：Edoxaban tosylate monohydrate
• CAS号：1229194-11-9
• 分子式：C₃₁H₄₀ClN₇O₈S₂
• 分子量：738.274
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) Factor Xa 抑制剂
• 发布时间：2018-09-09 13:28:00
• 更新时间：2026-07-01 16:15:47
• Edoxaban(DU-176)是口服的FXa抑制剂。

名称

• 中文名: 甲磺酸依度沙班
• 英文名: edoxaban tosylate hydrate
• 中文别名: 伊多塞班对甲苯磺酸盐一水化合物; 甲苯磺酸依度沙班一水合物; 依度沙班甲苯磺酸一水合物; 伊多塞班杂质29 对甲苯磺酸盐 一水合物; 艾多沙班对甲苯磺酸盐一水合物; 甲苯磺酸艾多沙班; 化合物 班对甲苯磺酸盐一水化合物; 伊多塞班对甲苯磺酸盐一水合物(FACTOR XA抑制剂); 甲磺酸艾多沙班; 伊多塞班杂质34 对甲苯磺酸盐 一水合物; 依杜沙班; 依度沙班甲磺酸盐; 苯磺酸伊多沙班; 艾多沙班对甲苯磺酸一水合物; 依多沙班甲磺酸盐一水合物; 依杜沙班对甲苯磺酸盐一水合物; 甲苯磺酸伊多沙班; 依度沙班杂质对照品; 甲苯磺酸依度沙班一水物; N1-(5-氯吡啶-2-基)-N2-((1S,2R,4S)-4-(二甲基甲酰胺基)-2-(5-甲基-4,5,6,7-四氢噻唑并[5,4-C]吡啶-2-甲酰胺基)环己基)草酰胺4-甲基苯磺酸盐一水合物; 依度沙班甲苯磺酸水合物; 依度沙班甲苯磺酸盐水合物; 依度沙班对甲苯磺酸盐一水化合物,10 MM DMSO 溶液; 依度沙班甲磺酸盐一水物; 依度沙班对甲苯磺酸盐一水; 对甲苯甲磺酸依度沙班; 依度沙班水合物; 依度沙班对甲苯磺酸盐一水合物; 依度沙班对甲苯磺酸盐一水化合物; 度沙班对甲苯磺酸盐一水化合物; 依多沙班对甲苯磺酸盐一水合物; FXA抑制剂(EDOXABAN TOSYLATE MONOHYDRATE); 依度沙班甲苯磺酸盐一水合物; 依多沙班甲苯磺酸盐水合物
• 英文别名: N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide,4-methylbenzenesulfonic acid,hydrate; Edoxaban (tosylate Monohydrate); Edoxaban tosilate hydrate (JAN); CS-1333; Edoxaban Tosylate Monohydrate, 10 mM in DMSO; Edoxaban p-toluenesulfonate monohydrate; Idoseban p-Toluenesulfonate Monohydrate; Edoxaban tosylate monohydrate(for Edoxaban); Lixiana; DU-176b tosylate Monohydrate; Edoxaban tosylate monohydrate (DU-176b); Edoxaban (TsOH salt hydrate); Yidu Saban Mesylate; Edoxaban tosilate monohydrate; Edoxaban Impurity 1; Edoxaban; Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate; N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-cboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate; LIXIANA (TN); Edoxaban Impurity 34 p-Toluenesulfonate Salt Monohydrate; Etoxaban methanesulfonate; Edoxaban Tosilate Monohydrate; Etoxaban p-toluenesulfonic acid; N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide 4-methylbenzenesulfonate hydrate (1:1:1); N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate; Edoxaban Tosylate Hydrate 1; Edoxaban (tosylate monohydrate); Edoxaban Tosylate Hydrate: N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-cboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate; Edoxaban tosilate; Edoxaban (tosylate Monohydrate) //BP; Etuxaban p-toluenesulfonate; Edoxaban Impurity 29 p-Toluenesulfonate Salt; Ethanediamide, N-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonat e, hydrate (1:1:1)

物化性质

• 分子式: C₃₁H₄₀ClN₇O₈S₂
• 分子量: 738.274
• 精确质量: 737.206848
• PSA: 236.85000
• LogP: 4.34050
• 外观性状: 白色至类白色粉末
• 储存条件: -20℃

生物活性

• 描述: Edoxaban(DU-176)是口服的FXa抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 因子Xa
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. [Epub ahead of print]

  [2]. Mendell J, Noveck RJ, Shi M. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol. 2012 Oct;60(4):335-41.

  [3]. Bathala MS, Masumoto H, Oguma T, Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos. 2012 Dec;40(12):2250-5.