1229194-11-9

• 常用中文名：伊多塞班对甲苯磺酸盐一水合物
• 常用英文名：Edoxaban tosylate monohydrate
• CAS号：1229194-11-9
• 分子式：C₃₁H₄₀ClN₇O₈S₂
• 分子量：738.274
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) Factor Xa 抑制剂
• 发布时间：2018-09-09 13:28:00
• 更新时间：2024-01-02 17:50:18
• Edoxaban(DU-176)是口服的FXa抑制剂。

名称

• 中文名: 甲磺酸依度沙班
• 英文名: edoxaban tosylate hydrate
• 中文别名: 伊多塞班对甲苯磺酸盐一水合物
• 英文别名: N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide,4-methylbenzenesulfonic acid,hydrate; Edoxaban tosylate monohydrate; N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide 4-methylbenzenesulfonate hydrate (1:1:1); Edoxaban tosilate monohydrate; Edoxaban tosilate hydrate (JAN); Edoxaban; Lixiana; Edoxaban tosilate; LIXIANA (TN); CS-1333; Ethanediamide, N-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonat e, hydrate (1:1:1); Edoxaban Impurity 1; Edoxaban (tosylate monohydrate)

物化性质

• 分子式: C₃₁H₄₀ClN₇O₈S₂
• 分子量: 738.274
• 精确质量: 737.206848
• PSA: 236.85000
• LogP: 4.34050
• 外观性状: 白色至类白色粉末
• 储存条件: -20℃

生物活性

• 描述: Edoxaban(DU-176)是口服的FXa抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 因子Xa
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. [Epub ahead of print]

  [2]. Mendell J, Noveck RJ, Shi M. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol. 2012 Oct;60(4):335-41.

  [3]. Bathala MS, Masumoto H, Oguma T, Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos. 2012 Dec;40(12):2250-5.