CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
KI0997000
-
CHEMICAL NAME :
-
Ethane, 1,1-dichloro-1-fluoro-
-
CAS REGISTRY NUMBER :
-
1717-00-6
-
BEILSTEIN REFERENCE NO. :
-
1731585
-
LAST UPDATED :
-
199806
-
DATA ITEMS CITED :
-
16
-
MOLECULAR FORMULA :
-
C2-H3-Cl2-F
-
MOLECULAR WEIGHT :
-
116.95
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
>5 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
56700 ppm/6H
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - ataxia
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
>2 gm/kg
-
TOXIC EFFECTS :
-
Liver - other changes
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
151 gm/m3/2H
-
TOXIC EFFECTS :
-
Behavioral - general anesthetic Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
>2 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
50 gm/m3/4H/4W-I
-
TOXIC EFFECTS :
-
Endocrine - evidence of thyroid hypofunction
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
18200 mg/m3/4H/26W-I
-
TOXIC EFFECTS :
-
Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - proteinuria Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
20000 ppm/6H/28D-I
-
TOXIC EFFECTS :
-
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
18200 mg/m3/4H/26W-I
-
TOXIC EFFECTS :
-
Blood - changes in leukocyte (WBC) count
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
DOSE :
-
20000 ppm/6H
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
DOSE :
-
20000 ppm/6H
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TEST SYSTEM :
-
Rodent - hamster Ovary
-
DOSE/DURATION :
-
10 pph/4H (Continuous)
-
REFERENCE :
-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,491,1995
|
