72203-93-1

• 常用中文名：1ALPHA,24,25-三羟基生素 D3
• 常用英文名：Calcitetrol
• CAS号：72203-93-1
• 分子式：C₂₇H₄₄O₄
• 分子量：432.63600
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-10-23 21:01:00
• 更新时间：2024-01-03 15:46:45
• Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。

名称

• 中文名: 1ALPHA,24,25-三羟基生素 D3
• 英文名: (1alpha,24R,25)-trihydroxy-Vitamin D3
• 英文别名: Calcitetrol

物化性质

• 分子式: C₂₇H₄₄O₄
• 分子量: 432.63600
• 精确质量: 432.32400
• PSA: 80.92000
• LogP: 4.67550
• 储存条件: 2-8℃

生物活性

• 描述: Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Johanna A. Huhtakangas, Christopher J. Olivera, June E. Bishop et al. The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro. Molecular Endocrinology November 1, 2004 vol. 18 no. 11 2660

  [2]. Robert A. Parise, Merrill J. Egorin, Beatriz Kanterewicz et al. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. International Journal of Cancer. Volume 119, Issue 8, pages 1819-1828, 15 October 2006

  [3]. Akiyoshi-Shibata M, Sakaki T, Ohyama Y, Noshiro M, Okuda K, Yabusaki Y. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli. Eur J Biochem. 1994 Sep 1;224(2):335-43.

  [4]. Sonoko Masuda, Valarie Byford, Alice Arabian et al. Altered Pharmacokinetics of 1α,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 in the Blood and Tissues of the 25-Hydroxyvitamin D-24-Hydroxylase (Cyp24a1) Null Mouse. Endocrinology February 1, 2005 vol.