73837-24-8

• 常用中文名：骨化三醇杂质
• 常用英文名：5,6-trans-Calcitriol
• CAS号：73837-24-8
• 分子式：C₂₇H₄₄O₃
• 分子量：416.637
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-09-11 20:31:25
• 更新时间：2026-07-12 11:12:35
• Calcitriol Impurities A是Calcitriol的杂质,Calcitriol是维生素D3的活性代谢物,能激活维生素D受体。

名称

• 中文名: 骨化三醇杂质
• 英文名: 5,6-trans-1alpha,25-Dihydroxyvitamin D3
• 中文别名: (1R,3S,5E)-4-亚甲基-5-[(2E)-2-[(1R,3AS,7AS)-八氢-1-[(1R; (1R,3S,5E)-4-亚甲基-5-[(2E)-2-[(1R,3AS,7AS)-八氢-1-[(1R)-5-羟基-1,5-二甲基己基]-7A-甲基-4H-茚-4-亚基]亚乙基]-1,3-环己二醇; 骨化三醇杂质1(骨化三醇杂质A); 5,6-骨化三醇; 反式骨化三醇(5,6-TRANS CALCITRIOL); 反式骨化三醇; 反式骨化三醇杂质; 维生素D5杂质; 5,6-反式-骨化三醇/5,6-trans-Calcitriol; 骨化三醇杂质A; 5,6-反式-1A,25-二羟基维生素 D3; 5,6-反式-钙三醇; 钙三醇杂质A; CALCITRIOL 杂质A(5,6- 反式骨化三醇); 骨化三醇杂质A(5,6-反式骨化三醇); 骨化三醇TRANS杂质; 5,6-反式-骨化三醇; (1R,3S,E)-5-(2-((1R,3aS,7,E)-1-((R)-6-羟基-6-甲基庚-2-基)-7a-甲基八氢-4H-茚-4-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇; 1Α,25-二羟基-5,6-反式-维生素D3; 5,6-TRANS-CALCITRIOL/反式骨化三醇
• 英文别名: Vitamin D5 Injection; Calcitriol Impurity 1; Calcitriol impurity A; Calcitriol Impurity A/5,6-trans Calcitriol/(1R,3S,E)-5-(2-((1R,3aS,7,E)-1-((R)-6-Hydroxy-6-methylhtan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; 5, 6-TRANS CALCITRIOL; 5-{2-[1-(5-Hydroxy-1,5-diMethyl-hexyl)-7a-Methyl-octahydro-inden-4-ylidene]-ethylidene}-4-Methylene; (1S,3R,5E,7E)-9,10-Secocholesta-5,7,10-triene-1,3,25-triol; (1α,3β,5E,7E)- 9,10-Secocholesta-5,7,10-triene-1,3,25-triol; 5,6-trans-1a,25-DihydroxyvitaminD3; (1R,3S,E)-5-((E)-2-((1R,3aS,7-1-((R)-6-Hydroxy-6-methyl-ht-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexan-1,3-diol; 5-{2-[1-(5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol; Calcitriol Impurity A (5,6-trans Calcitriol); 5-[(3R,5S)-3-amino-5-(trifluoromethyl)-1-piperidinyl]; InterMediate of Calcitriol; (1R,3S,E)-5-(2-((1R,3aS,7,E)-1-((R)-6-Hydroxy-6-methylhtan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; Calcitriol Impurities A; (1R,3S,5E)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-diMethylhexyl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1R,3S,E)-5-((E)-2-((1R,3aS,7-1-((R)-6-hydroxy-6-methylhtan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; 1,25-Dihydrox; 5,6-trans-Calcitrio; Calcitriol Impurity 1(Calcitriol Impurity A); 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5E); 5,6-trans-1a,25-Dihydroxyvitamin D3; TRANS CALCITRIOL; (6R)-6-[(1R,4E,7-4-[(2Z)-2-[(3S,5R)-3,5-bis[[tert-butyl(diMethyl)silyl]oxy]-2-Methylene-cyclohexylidene]ethylidene]-7a-Methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-Methyl-htan-2-ol; (6R)-6-[(1R,4E,7-4-[(2Z)-2-[(3S,5R)-3,5-bis[[tert-butyl(d; (1R,3S,E)-5-((E)-2-((1R,3aS,7-1-((R)-6-hydroxy-6-Methylhtan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexane-1,3-diol; N-1 intermediate of calcitrol

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 565.0±50.0 °C at 760 mmHg
• 分子式: C₂₇H₄₄O₃
• 分子量: 416.637
• 闪点: 238.4±24.7 °C
• 精确质量: 416.329041
• PSA: 60.69000
• LogP: 6.12
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.547
• 储存条件: 2-8℃

生物活性

• 描述: Calcitriol Impurities A是Calcitriol的杂质,Calcitriol是维生素D3的活性代谢物,能激活维生素D受体。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病

合成路线

140710-98-1 ~80% 73837-24-8

文献：Manchand, Percy S.; Yinnikouros, George P.; Belica, Peter S.; Madan, Pradeep Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6574 - 6581

157809-60-4 ~% 73837-24-8

文献：Journal of the American Chemical Society, , vol. 116, # 14 p. 6207 - 6216

32222-06-3 ~% 73837-24-8

文献：Journal of the American Chemical Society, , vol. 116, # 14 p. 6207 - 6216

170081-46-6 ~% 73837-24-8

文献：Journal of Organic Chemistry, , vol. 60, # 20 p. 6574 - 6581

128387-35-9 ~% 73837-24-8

文献：Journal of Organic Chemistry, , vol. 60, # 20 p. 6574 - 6581

147125-06-2 ~% 73837-24-8

文献：Journal of Organic Chemistry, , vol. 60, # 20 p. 6574 - 6581

169900-32-7 ~% 73837-24-8

文献：Journal of Organic Chemistry, , vol. 60, # 20 p. 6574 - 6581

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