471905-41-6

471905-41-6结构式

中文名	盐霉素
英文名	cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
中文别名	3-(顺式-4-((4-氯苯基)磺酰基)-4-(2,5-二氟苯基)环己基)丙酸沙利霉素顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸, 一种适度有效的Γ-SECRETASE(Γ-分泌酶)抑制剂 MK-0752,γ-secretase（γ-分泌酶）抑制剂 MK-0752,γ-secretase(γ-分泌酶)抑制剂 MK-0752,Γ-SECRETASE(Γ-分泌酶)抑制剂顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸
英文别名	cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanropanoic acid MK-0752 MK-0752, 10 mM in DMSO 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid MK-0752, >= 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid Cyclohexanropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis mk-0752 mk0752 cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanropanoic acid MK-0752/MK0752 3-((1R,4S)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid a moderately potent γ-secretase inhibitor Aβ40,MK 0752,inhibit,brier,γ-secretase,blood-brain,Inhibitor,MK-0752,CNS,MK0752,Gamma secretase 3-{cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}propanoic acid

描述	MK-0752是γ-secretase抑制剂,能减少Aβ40的产生,IC50为5 nM。
相关类别	信号通路 >> 神经信号通路 >> γ分泌酶信号通路 >> 干细胞及 Wnt 通路 >> γ分泌酶研究领域 >> 神经疾病
参考文献	[1]. Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci, 2010, 30(19), 6743-6750. [2]. Harrison H, et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res, 2010, 70(2), 709-718.