103146-26-5

• 常用中文名：4-[4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基]-3-羟甲基苯腈氢溴酸盐
• 常用英文名：4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide
• CAS号：103146-26-5
• 分子式：C₂₀H₂₄BrFN₂O₂
• 分子量：423.319
• 相关类别： 有机原料 有机氟化合物 氟苯腈系列
• 发布时间：2019-01-10 16:22:37
• 更新时间：2026-07-01 12:01:02

名称

• 中文名: 4-[4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基]-3-羟甲基苯腈氢溴酸盐
• 英文名: 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromide
• 中文别名: 4-[4-(二甲氨基)-1; 4-4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基-3-羟甲基苯腈氢溴酸盐; 氢溴酸西酞二醇; 西酞普兰中间体-2; 西酞普兰杂质28(依他普仑杂质E); 4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈氢溴酸盐,草酸依地普仑/西酞普兰中间体; 西酞普兰二羟基杂质氢溴酸盐; 4-[4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基]-3-羟甲基苯腈氢溴酸盐 103-5; 艾司西酞普兰INT D 艾司西酞普兰-A04; 草酸艾司西酞普兰杂质E盐酸盐; 艾司西酞普兰-A04; 4-[(4-二甲基氨基)-1-(4-氟苯基)-1-羟基丁基]-3-羟基甲基苯腈氢溴酸盐(二羟氢溴酸盐); 4-[4-(二甲氨基)-1-(4-氟; 艾司西酞普兰杂质16(氢溴酸盐); 4-(4-二甲基-1-对氟苯基-1-羟基丁基-3-羟甲基)苯腈氢溴酸盐; 二醇氢溴酸盐; 右酞普兰中间体; 4-(4-二甲基-1-对氟苯基-1-羟基丁基-3-羟甲基)苯腈氢溴酸盐/草酸西酞普兰; 4-(4-(二甲基氨基)-1-(4-氟苯基)-1-羟丁基)-3-(羟甲基)苯腈氢溴酸盐; 氢溴酸西酞醇; 草酸艾司西酞普兰 中间体; 4-(4-(二甲基氨基)-1-(4-氟苯基)-1-羟基丁基)-3-(羟甲基)苯甲腈氢溴酸盐; 4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈氢溴酸盐,草酸依地普仑中间体; (-)4[4-(二甲胺基)-1-(4'-氟苯基)-1(羟丁基)-3-(羟甲基)苯腈.氢溴酸盐; 氢溴酸西他二醇; 西酞普兰杂质38; 西酞普兰二羟基杂质氢溴酸盐(西酞普兰杂质1)
• 英文别名: 4-[4-(Dimethylamino)-1-(4-Fluorophenyl)-1-HydroxyButyl]-3-(Hydroxymethyl)-Benzon; 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide (1:1); Benzonitrile, 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-, monohydrobromide; 4-[4-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-1-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITRILE, MONOHYDROBROMIDE; 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxyb; 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromid; UNII:5G2RC58G1K; 5-Cyano Diol Hbr CAS NO. 103-5 (Used in Manufacture of Citalopram & Escitalopram); Citadiol Hydrobromide (4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile Hydrobromide); Benzonitrile, 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-, hydrobromide; Benzonitrile,4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-,hydrobromide (1:1); 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide###4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile; Cyano Diol Compound HCl; Citalopram Impurity 2; Benzonitrile, 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-, hydrobromide (1:1); Escitalopram Impurity(Hydrobromide); Noradrenaline Impurity 64; 4-[(4-DIMETHYLAMINO)-1-(4-FLUORO PHENYL)-1-HYDROXYBUTYL]-3-HYDROXY-METHYL BENZONITRILE HYDROBROMIDE; Citalopram Dihydroxy Impurity HBr; Citadiol Hydrobromide (4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benz; Citadiol Hydrobromide; 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide; Escitalopram Impurity E; 4-(4-DIMETHYLAMINO)-1(4-FLUOROPHENYL)-1- HYDROXYBUTYL-3 (HYDROXY METHYL) BENZONIT RILE HYDRO BROMIDE (SYNONYMS:DIOL HBR); Citalopram Impurity 28（Escitalopram Impurity E）; MFCD08436978; 5-Bromo-1-(3-Dimethylamino Propyl)-1-(4-Fluoro Phenly)-1,3-Dihydro Isobenzofuran-(Bromo Cyclized/Citalopram HBR Stage); (4RS)-4-[4-Cyano-2-(hydroxymethyl)phenyl]-4-(4-fluorophenyl)-4-hydroxy-N,N-dimethylbutan 1-aminum; 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobro; Citadiol HBr; Citalol Hydrobromide; Escitalopram Oxalate Impurity E as Hydrobromide

物化性质

• 沸点: 561.6ºC at 760 mmHg
• 熔点: 201-205ºC(lit.)
• 分子式: C₂₀H₂₄BrFN₂O₂
• 分子量: 423.319
• 闪点: 293.5ºC
• 精确质量: 422.100525
• PSA: 67.49000
• LogP: 3.72548
• 外观性状: 淡黄色或白色结晶粉末
• 蒸汽压: 1.89E-13mmHg at 25°C
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37
• WGK德国: 3
• 海关编码: 2926909090

合成路线

19070-16-7 82104-74-3 352-13-6 ~% 103146-26-5

文献：US2010/87664 A1, ; Page/Page column 4 ;

上下游产品

上游产品  3
19070-16-7 82104-74-3 352-13-6
下游产品  2
59729-32-7 103146-25-4

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%