103146-25-4

• 常用中文名：4-(4-(二甲基氨基)-1-(4-氟苯基)-1-羟丁基)-3-(羟基甲基)苄腈
• 常用英文名：UNII:2FZ7LD4B44
• CAS号：103146-25-4
• 分子式：C₂₀H₂₃FN₂O₂
• 分子量：342.407
• 相关类别： 有机原料 有机氟化合物 氟苯腈系列
• 发布时间：2018-12-20 13:05:15
• 更新时间：2026-07-15 19:57:01

名称

• 中文名: 4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈
• 英文名: 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
• 中文别名: (+)4-(4-二甲基-1-对氟苯基-1-羟基丁基-3-羟甲基)苯腈; 艾司西酞普兰INT C 艾司西酞普兰-A03; 西酞普兰杂质O; 4-[4-(二甲基氨基)-1-(4-氟苯基)-1-羟基丁基]-3-(羟甲基)苯甲腈; 4-[4-(二甲基胺基)-1-(4-氟苯基)-1-羟基丁基]-3-羟甲基苯腈; 4-(4-(二甲基氨基)-1-(4-氟苯基)-1-羟丁基)-3-(羟基甲基)苯甲腈; 艾司西酞普兰杂质E; 依西酞普兰杂质5; 4-(4-二甲基-1-对氟苯基-1-羟基丁基-3-羟甲基)苯腈; 目前提供的是氢溴酸盐的见103-5; 艾司西酞普兰-A03; 4-[(4-二甲基氨基)-1-(4-氟苯基)-1-羟基丁基]-3-羟基甲基苯腈; 艾司西酞普兰杂质E(已停用,见RM-C090100); 艾司西酞普兰杂质05; 4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)氰基苯; 艾司西酞普兰中间体 A; 4-(4-二甲氨基)-1-(4-氟苯基)-1-(羟基丁基)-3-(羟基甲基)-苯腈; 艾司西酞普兰杂质5; 艾司西酞普兰杂质W
• 英文别名: Citadiol; Q1R CCN FXQR DF&3N1&1; 4-[4-(Dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile; (R,S)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile; 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile diol; 1-hydroxybutyl); 4-(4-(Dimethylamino)-1-(4-Fluorophenyl)-1-Hydroxybutyl)-3- (hydroxymethyl) Benzonitrile (Diol base/HCl/HBr); 4-[(4’-Dimethylamino)-1-(4”-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile; 4-(4-DIMETHYLAMINO)-1-(4-FLUOROPHENY L)-1-(HYDROXY BUTYL]-3-(HYDROXYLMETHYL)-BENZONITRILE; 4‐[4‐(Dimetylamino)‐1‐(4’‐ fluorophenyl)‐1‐hydroxybutyl]‐ 3(hydroxymethyl)benzonitrile (CDB); UNII-2FZ7LD4B44; Citalopram Diol BaseQ: What is Citalopram Diol Base Q: What is the CAS Number of Citalopram Diol Base Q: What is the storage condition of Citalopram Diol Base Q: What e the applications of Citalopram Diol Base; 14β-Hydroxy-7-O-(triethylsilyl) Baccatin III 1; 4-[(S)-4-N,N-Dimethylamino-1-(4-fluoro-phenyl)-1-hydroxy-butyl]-3-hydroxymethyl-benzonitrile; 1-(4-fluorophenyl); (4RS)-4-[4-cyano-2-(hydroxymethyl)phenyl]-4-(4- fluorophenyl)-4-hydroxy-N,N-dimethylbutan-1-aminium; (-)4-[4-(dimethylamino)-1-(4’-fluorophenyl)-1-(hydroxybutyl-3-(hydroxymethyl)] benzonitrile .hydrobromic (Intermediate of Citalopram); 4-[4-(Dimethyl amino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyl methyl) benzonitrile (Cyano diol); 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile; 4-(4-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-1-HYDROXY-1-BUTYL)-3-(HYDROXYMETHYL)BENZONITRILE HYDROBROMIDE; (RS)-4-(4-Dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile; (RS)-(+/-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile; Citalopram Impurity O; Benzonitrile,4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl); 4-[(4-Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile (Diol base); 4-[4-(Dimethylamino)-1-(4'-Fluorophenyl)-1-Hydroxybutyl]-3-(; Escitalopram Impurity 5; EscitalopraM interMediate A; (+)4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxy-butyl]-3-(hydroxymethyl)-benzonitrile

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 537.2±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₃FN₂O₂
• 分子量: 342.407
• 闪点: 278.7±30.1 °C
• 精确质量: 342.174347
• PSA: 67.49000
• LogP: 2.22
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.598
• 储存条件: 2-8°C，干燥，密封

安全

• 危害码 (欧洲): Xi
• 海关编码: 2926909090

合成路线

103146-26-5 ~% 103146-25-4

文献：US2010/249438 A1, ; Page/Page column 4 ;

19070-16-7 82104-74-3 460-00-4 ~% 103146-25-4

文献：WO2006/106531 A1, ; Page/Page column 11 ;

717133-25-0 ~% 103146-25-4

文献：EP1700851 A1, ; Page/Page column 9 ;

260371-16-2 19070-16-7 ~% 103146-25-4

文献：WO2005/77927 A1, ; Page/Page column 10-11 ;

19070-16-7 82104-74-3 352-13-6 ~92% 103146-25-4

文献：Zong, Hua; Huang, Huayin; Liu, Junfeng; Bian, Guangling; Song, Ling Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4645 - 4652

460-00-4 ~% 103146-25-4

文献：US2011/92719 A1, ;

5407-04-5 ~% 103146-25-4

文献：US2011/92719 A1, ;

上下游产品

上游产品  8
103146-26-5 19070-16-7 82104-74-3 460-00-4
717133-25-0 260371-16-2 352-13-6 5407-04-5
下游产品  6
488787-59-3 59729-32-7 59729-33-8 64372-56-1
128196-01-0 219861-08-2

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%