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134-80-5

134-80-5结构式

常用中文名：盐酸安非拉酮
常用英文名：Diethylpropion Hydrochloride
CAS号：134-80-5
分子式：C₁₃H₂₀ClNO
分子量：241.757
相关类别：原料药神经系统用药其它神经系统用药
发布时间：2018-03-18 08:00:00
更新时间：2024-01-06 13:53:44

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中文名	盐酸安非拉酮
英文名	diethylpropion hydrochloride
中文别名	安非拉酮盐酸盐 2-(二乙基氨基)-1-苯基-1-丙酮盐酸盐
英文别名	1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride (1:1) Prefamone Keramik Keramin Diethylpropione hydrochloride 2-(diéthylamino)-1-phénylpropan-1-one chlorhydrate 2-(Diethylamino)-1-phenyl-1-propanone hydrochloride (1:1) 2-(Diethylamino)-1-phenylpropan-1-onhydrochlorid Diethylpropion Hydrochloride Regenon ANOREX Danylen Frekentine Tylinal 2-(diethylamino)-1-phenylpropan-1-one,hydrochloride EINECS 205-156-5 2-(diethylamino)-1-phenylpropan-1-one hydrochloride 2-Diethylaminopropiophenone Hydrochloride a-Benzoyltriethylamine Hydrochloride Anfamon 2-(Diethylamino)-1-phenylpropan-1-one hydrochloride (1:1) UNII:19V2PL39NG Amfepramone HCL Magrene Modulor Parabolin

密度	0.972g/cm3
沸点	292ºC at 760mmHg
熔点	180-181ºC
分子式	C₁₃H₂₀ClNO
分子量	241.757
闪点	95.4ºC
精确质量	241.123337
PSA	20.31000
LogP	3.40160
蒸汽压	0.00189mmHg at 25°C
储存条件	Controlled Substance, -20°C Freezer
分子结构	1、摩尔折射率：63.12 2、摩尔体积（cm³/mol）：211.1 3、等张比容（90.2K）：514.4 4、表面张力（dyne/cm）：35.2 5、极化率（10-24cm3）：25.02
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:5 5.互变异构体数量:2 6.拓扑分子极性表面积20.3 7.重原子数量:16 8.表面电荷:0 9.复杂度:193 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH0360000

CHEMICAL NAME :: Propiophenone, 2-(diethylamino)-, hydrochloride

CAS REGISTRY NUMBER :: 134-80-5

LAST UPDATED :: 199606

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H19-N-O.Cl-H

MOLECULAR WEIGHT :: 241.79

WISWESSER LINE NOTATION :: 2N2&Y1&VR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 139 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 17,121,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 385 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - excitement Skin and Appendages - hair

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,37,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 17,182,1960

符号	GHS07
信号词	Warning
危害声明	H302 + H312 + H332
警示性声明	P261-P280-P301 + P312 + P330
危害码 (欧洲)	F,T
风险声明 (欧洲)	11-23/24/25-39/23/24/25-20/21/22
安全声明 (欧洲)	7-16-36/37-45-36
危险品运输编码	UN1230 - class 3 - PG 2 - Methanol, solution
海关编码	2922399090

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109-89-7 579-07-7 65-85-0

海关编码	2922399090
中文概述	2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%