16754-80-6

• 常用中文名：6-氯-7-脱氮-9-(Β-D-呋喃核糖基)嘌呤
• 常用英文名：6-Chloro-7-Deazapurine-Beta-D-Riboside
• CAS号：16754-80-6
• 分子式：C₁₁H₁₂ClN₃O₄
• 分子量：285.68400
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2017-04-04 18:14:50
• 更新时间：2026-07-14 16:43:46
• 氯-7-脱氮嘌呤-β-D-核糖是一种核苷衍生物,具有抗真菌活性[1]。

名称

• 中文名: (2R,3R,4S,5R)-2-(4-氯-7H-吡咯并[2,3-d]嘧啶-7-基)-5-(羟甲基)四氢呋喃-3,4-二醇
• 英文名: 6-Chloro-7-deazapurine-b-D-riboside
• 中文别名: (2R,3R,4S,5R)-2-(4-氯-7H-吡咯并[2,3-D]嘧啶-7-基)-5-(羟甲基)四氢呋喃-3,4-二醇; 6-氯-9-(Β-D-呋喃核糖基)-7-脱氮嘌呤; 4-氯-7-(Β-D-呋喃核糖基)-7H-吡咯并[2,3-D]嘧啶; 6-氯-9-(BETA-D-呋喃核糖基)-7-脱氮嘌呤; 6-氯-7-脱氮嘌呤-BETA-D-核糖甙; 6-氯-7-脱氮嘌呤-Β-D-核糖苷
• 英文别名: 6-Chloro-7-deazapurine-β-D-riboside; 6-Chloro-7-deaza-9-(β-D-ribofuranosyl)purine; 6-Chloro-7-deazapurine riboside; 2-{4-CHLOROPYRROLO[2,3-D]PYRIMIDIN-7-YL}-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL; 6-CHLORO-7-DEAZAPURINE-SS-D-RIBOSIDE; 6-Deamino-6-chlorotubercidin; 6-Chloro-7-deazapurine-9-b-D-ribofuranose; 4-Chloro-7-(D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine; (2R,3R,4S,5R)-2-(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-7-β-D-ribofuranosyl; 4-chloro-7-β-D-ribofuranosyl-7H-Pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazapurine-9-b-D-ribofuranose,4-Chloro-7-(b-D-ribofuranosyl)-7H-pyrrolo [2.3-d]pyrimidine; (2R,3R,4S,5R)-2-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 6-Chloro-9-(β-D-ribofuranosyl)-7-dezapurine; 6-Chloro-9-(D-ribofuranosyl)-7-deazapurine; 6-Chloro-9-(beta-D-ribofuranosyl)-7-dezapurine; 4-Chloro-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, 6-Chloro-7-deazapurine-9--D-ribofuranose; 6-deamino-6-chlorotubercidine; 4-Chloro-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine; Fungal,antifungal,6 Chloro 7 deazapurine β D riboside,riboside,inhibit,6Chloro7deazapurineβDriboside,Inhibitor; 6-Chloro-9-(beta-D-ribofuranosyl)-7-deazapurine; 6-Chloro-7-deazapurine-9-D-ribofuranose; (2R,3R,4S,5R)-2-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol

物化性质

• 密度: 1.87g/cm3
• 沸点: 591.4ºC at 760mmHg
• 熔点: 160-162ºC
• 分子式: C₁₁H₁₂ClN₃O₄
• 分子量: 285.68400
• 闪点: 311.5ºC
• 精确质量: 285.05200
• PSA: 100.63000
• 蒸汽压: 7.8E-15mmHg at 25°C
• 折射率: 1.786
• 储存条件: 2-8°C，存于惰性气体中

生物活性

• 描述: 氯-7-脱氮嘌呤-β-D-核糖是一种核苷衍生物,具有抗真菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Hajime Iwamura, et al. Antifungal Activity of Substituted 7-(β-D-Ribofuranosyl)pyrrolo-[2,3-d]pyrimidines. Agricultural and Biological Chemistry, Volume 40, Issue 7, 1 July 1976, Pages

安全

• 危害码 (欧洲): Xn

合成路线

1039752-77-6 ~85% 120401-32-3 16754-80-6

文献：Journal of Medicinal Chemistry, , vol. 51, # 13 p. 3934 - 3945

115479-39-5 ~10% 16754-80-6

文献：Ramasamy; Imamura; Robins; Revankar Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898

102690-94-8 ~% 16754-80-6

文献：Helvetica Chimica Acta, , vol. 71, # 6 p. 1573 - 1585

75921-20-9 ~% 16754-80-6

文献：Helvetica Chimica Acta, , vol. 71, # 6 p. 1573 - 1585

3680-69-1 ~% 16754-80-6

文献：Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1893 - 1898

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