102805-45-8

• 常用中文名：[D-p-Cl-Phe6,Leu17]-VIP
• 常用英文名：(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt
• CAS号：102805-45-8
• 分子式：C₁₄₈H₂₃₉ClN₄₄O₄₂
• 分子量：3342.204
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-11-18 14:31:55
• 更新时间：2026-07-03 18:35:14
• [D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂,IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素,促胰液素和 GRF 受体无活性。

名称

• 中文名: [D-p-Cl-Phe6, Leu17]-七磷酸庚糖血管活性肠肽,三氟乙酸盐
• 英文名: L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide
• 中文别名: 6-(4-氯-D-苯丙氨酸)-17-L-亮氨酸-血管活性小肠二十八肽(猪); 化合物 [D-P-CL-PHE6,LEU17]-VIP; D-P-CL-PHE6, LEU17]-七磷酸庚糖血管活性肠肽,三氟乙酸盐; [D-对氯苯丙氨酸, 亮氨酸1]-血管活性肠肽; 血管活性肠肽受体拮抗剂多肽[DP-CL-PHE6,LEU17] -VIP
• 英文别名: HIS-SER-ASP-ALA-VAL-PCLDPHE-THR-ASP-ASN-TYR-THR-G-LEU-G-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2 [HSDAV-PCLDPHE-TDNYTRKQLAVKKYLNSILN-NH2]; Vasoactive intestinal octacosaptide (pig), 6-(4-chloro-D-phenylalanine)-17-L-leucine; H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-g-Leu-g-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2; [(4CL)DPHE6,LEU17] VASOACTIVE INTESTINAL PTIDE; [D-P-CL-PHE6,LEU17]-VASOACTIVE INTESTINAL PTIDE HUMAN; (D-P-CL-PHE6,LEU17)-VASOACTIVE*INTESTINA L PTIDE H; (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-g-Leu-g-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 trifluoroacetate salt; (p-Chloro-D-Phe6,Leu17)-VIP; VIP rector antagonist (Human, Bovine, Porcine, Rat); L-His-L-Ser-L-Asp-L-Ala-L-Val-4-Chloro-D-Phe-L-Thr-L-Asp-L-Asn-L-Tyr-L-Thr-L-g-L-Leu-L-g-L-Lys-L-Gln-L-Leu-L-Ala-L-Val-L-Lys-L-Lys-L-Tyr-L-Leu-L-Asn-L-Ser-L-Ile-L-Leu-L-Asn-NH2; 4-chloro-phe-leu-vasoactiveintestinalptid; HIS-SER-ASP-ALA-VAL-PCL-D-PHE-THR-ASP-ASN-TYR-THR-G-LEU-G-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2; (p-Chloro-D-Phe,Leu)-VIP (human, mouse, rat) trifluoroacetate salt; D-p-Cl-Phe6, Leu17]-Vasoactive Intestinal Ptide human, porcine, rat >= (HPLC); HIS-SER-ASP-ALA-VAL-(PCL)DPHE-THR-ASP-ASN-TYR-THR-G-LEU-G-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2; (p-Chloro-D-Phe6,Leu17)-VIP (huMan, Mouse, rat); Vip, 4-cl-Phe-Leu; [P-CHLORO-D-PHE6,LEU17]-VIP, HUMAN, PORCINE, RAT; H-HIS-SER-ASP-ALA-VAL-D-PHE(4-CL)-THR-ASP-ASN-TYR-THR-G-LEU-G-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2; L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L -alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide; Vasoactive intestinal ptide, 4-chlorophenylalanyl-leucine; 6-(4-Chlorophenylalanyl)-17-leucine-vip; [PCL-D-PHE6, LEU17]VIP, HUMAN, PORCINE, RAT; 6-(4-Chloro-D-Phenylalanine)-17-L-Leucine-Vasoactive Intestinaloctacosapeptide (Swine); [(4CL)DPHE6,LEU17] VIP; [D-P-CL-PHE6,LEU17]-VASOACTIVE INTESTINAL PTIDE; [d-p-cl-phe6,leu17]-vasoactiveintestinalptidefromprocine; Vasoactive intestinal octacosaptide (swine), 6-(4-chloro-D-phenylalanine)-17-L-leucine; [D-P-CL-PHE(6),LEU]-VASOACTIVE INTESTINAL PTIDE HUMAN, PORCINE, RAT; l-vip; (p-Chloro-D-Phe6,Leu17)-VIP (human, bovine, porcine, rat)|[4ClDPhe6,Leu17] VIP; (P-CHLORO-D-PHE6,LEU17)-VIP; [4ClDPhe6,Leu17] VIP; vasoactive intestinal ptide, 4-chloro-Phe-Leu; [P-CHLORO-D-PHE6, LEU17]-VASOACTIVE INTESTINAL PTIDE (HUMAN, BOVINE, PORCINE, RAT); (p-Chloro-D-Phe,Leu1)-VIP; 6-(4-Chloro-Phe)-17-Leu-vasoactive intestinal ptide; (D-PHE(4-CL)6,LEU17)-VIP (HUMAN,BOVINE, PORCINE, RAT); (P-CHLORO-D-PHE6,LEU17)-VIP (HUMAN, BOVINE, PORCINE, RAT); [ D -p-Cl-Phe6, Leu17]-Vasoactive Intestinal Ptide human, porcine, rat; [d-p-cl-phe6, leu17]-vip

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₄₈H₂₃₉ClN₄₄O₄₂
• 分子量: 3342.204
• 精确质量: 3339.760742
• PSA: 1453.69000
• LogP: -4.01
• 折射率: 1.657
• 储存条件: -20°C

生物活性

• 描述: [D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂,IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素,促胰液素和 GRF 受体无活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点:

  IC50: 125.8 nM (VIP receptor)[1]

• 参考文献:

  [1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86.

  [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7.

  [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport