148741-30-4

• 常用中文名：Tyrphostin AG 879
• 常用英文名：Tyrphostin AG 879
• CAS号：148741-30-4
• 分子式：C₁₈H₂₄N₂OS
• 分子量：316.461
• 相关类别： 生物化工 抑制剂 蛋白酪氨酸激酶
• 发布时间：2018-11-29 22:37:48
• 更新时间：2026-07-09 04:03:23
• AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。

名称

• 中文名: Tyrphostin AG 879
• 英文名: (E)-3-amino-2-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
• 中文别名: 抑制剂Tyrphostin AG; (E)-2-氰基-3-(3,5-二叔丁基-4-羟基苯基)丙-2-烯硫酰胺; TYRPHOSTIN AG 879 酪氨酸激酶的抑制剂; TRKA磷酸化抑制剂; (E)-2-氰基-3-(3,5-二叔丁基-4-羟基苯基)丙-2-烯硫代酰胺; Tyrphostin AG 879试剂; Tyrphostin AG 879 10mM * 1mL in DMSO试剂; AG-879,TRKA RECTOR抑制剂
• 英文别名: α-cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide; AG 879; TYRPHOSTIN; 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (E); TYRPHOSTIN AG 879 //BP; AG 879 - - Calbiochem; BMK1-D4; 2-CYANO-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)PROP-2-ENETHIOAMIDE; Tyrphostin AG 879 ，S2816; AG-879; (2E)-2-Cyano-3-[4-hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]-2-propenethioamide; 2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E); (2E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide; TYRPHOSTIN AG; AG-879, TrkA rector inhibitor; ALPHA-CYANO-(3,5-DI-TERT-BUTYL-4-HYDROXY)THIOCINNAMAMIDE; (E)-3-AMINO-2-[(3,5-DITERT-BUTYL-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]-3-SULFANYLPROP-2-ENENITRILE; ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE; (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide; 2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-,(2E); (E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide; (3,5-DI-T-BUTYL-4-HYDROXYBENZYLIDENE)THIOCYANOACETAMIDE; AG 879;AG-879; Tyrphostin AG 879, 10 mM in DMSO; (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide; Lopac-T-2067

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 432.7±55.0 °C at 760 mmHg
• 熔点: 232 °C
• 分子式: C₁₈H₂₄N₂OS
• 分子量: 316.461
• 闪点: 215.5±31.5 °C
• 精确质量: 316.160919
• PSA: 102.13000
• LogP: 4.76
• 外观性状: 固体;Light yellow to Yellow to Orange powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.600
• 储存条件: Store at -20°C
• 水溶解性: DMSO: at 26 mg/mlsoluble

生物活性

• 描述: AG879是酪氨酸激酶的抑制剂,能够抑制TrKA的磷酸化,但不能抑制TrKB 和TrKC,也是高选择性的ErbB2激酶抑制剂。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> Trk Receptor
  研究领域 >> 癌症
• 参考文献:

  [1]. Rende M et al. Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs. 2006 Sep;17(8):929-41.

  [2]. Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11.

  [3]. Ting AK et al. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 2011 Jan 5;31(1):15-25.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2930909090

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%