Tyrphostin AG 879

• 常用名: Tyrphostin AG 879
• 英文名: Tyrphostin AG 879
• CAS号: 148741-30-4
• 分子量: 316.461
• 密度: 1.1±0.1 g/cm3
• 沸点: 432.7±55.0 °C at 760 mmHg
• 分子式: C₁₈H₂₄N₂OS
• 熔点: 232 °C
• 闪点: 215.5±31.5 °C

Tyrphostin AG 879用途

AG879是酪氨酸激酶的抑制剂,能够抑制TrKA的磷酸化,但不能抑制TrKB 和TrKC,也是高选择性的ErbB2激酶抑制剂。

Tyrphostin AG 879名称

• 中文名: Tyrphostin AG 879
• 英文名: (E)-3-amino-2-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile

Tyrphostin AG 879生物活性

• 描述: AG879是酪氨酸激酶的抑制剂,能够抑制TrKA的磷酸化,但不能抑制TrKB 和TrKC,也是高选择性的ErbB2激酶抑制剂。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> Trk Receptor
  研究领域 >> 癌症
• 参考文献:

  [1]. Rende M et al. Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs. 2006 Sep;17(8):929-41.

  [2]. Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11.

  [3]. Ting AK et al. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 2011 Jan 5;31(1):15-25.

Tyrphostin AG 879物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 432.7±55.0 °C at 760 mmHg
• 熔点: 232 °C
• 分子式: C₁₈H₂₄N₂OS
• 分子量: 316.461
• 闪点: 215.5±31.5 °C
• 精确质量: 316.160919
• PSA: 102.13000
• LogP: 4.76
• InChIKey: XRZYELWZLNAXGE-KPKJPENVSA-N
• SMILES: CC(C)(C)c1cc(C=C(C#N)C(N)=S)cc(C(C)(C)C)c1O
• 外观性状: 固体;Light yellow to Yellow to Orange powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.600
• 储存条件: Store at -20°C
• 水溶解性: DMSO: at 26 mg/mlsoluble

Tyrphostin AG 879安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2930909090

Tyrphostin AG 879海关

• 海关编码: 2930909090
• 中文概述: 2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Tyrphostin AG 879靶点实验

查看更多实验

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5550262

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Tyrphostin AG 879英文别名

• AG 879
• BMK1-D4
• (2E)-2-Cyano-3-[4-hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]-2-propenethioamide
• 2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-,(2E)
• Lopac-T-2067
• Tyrphostin AG 879
• (2E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide