1198-77-2

• 常用中文名：尿酸钠
• 常用英文名：Sodium Urate
• CAS号：1198-77-2
• 分子式：C₅H₃N₄NaO₃
• 分子量：190.092
• 相关类别： 生物化工 核苷类药物 核苷酸及其类似物
• 发布时间：2018-08-14 13:35:14
• 更新时间：2024-01-02 19:30:47
• 尿酸钠是氧自由基的清除剂,是一种非常重要的抗氧化剂,有助于维持血压的稳定和抗氧化应激。尿酸钠可以去除活性氧物种(ROS),如单线态氧和过氧亚硝酸盐,抑制脂质过氧化[1][2]。

名称

• 中文名: 尿酸二氢钠
• 英文名: uric acid sodium salt
• 中文别名: 尿酸钠; 尿酸 钠盐; 尿酸钠盐
• 英文别名: Harnsaeure,Natrium-Salz; uric acid,sodium-salt; 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, sodium salt (1:1); uric; SODIUM ACID URATE SODIUM SALT; SODIUM ACID URATE; MFCD00067310; uricacidsodium; URIC ACID MONOSODIUM SALT; Uric acid, monosodium salt; Monosodium Urate; Sodium 6,8-dioxo-6,7,8,9-tetrahydro-3H-purin-2-olate; Uric acid monosodium; Sodium Urate; 3H-Purine-6,8-dione, 7,9-dihydro-2-hydroxy-, sodium salt (1:1)

物化性质

• 分子式: C₅H₃N₄NaO₃
• 分子量: 190.092
• 精确质量: 190.010284
• PSA: 117.46000
• 外观性状: 白色至白色带有黄色粉末
• 储存条件: 室温
• 稳定性: Stable.
• 计算化学:

  1、 氢键供体数量：3

  2、 氢键受体数量：4

  3、 可旋转化学键数量：0

  4、 互变异构体数量：12

  5、 拓扑分子极性表面积（TPSA）：88.3

  6、 重原子数量：13

  7、 表面电荷：0

  8、 复杂度：337

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多: 1. 性状：白色硬颗粒结晶或结晶性粉末。 2. 密度（ g/cm ³,20 ℃ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,15mmHg）：未确定

  7. 折射率（n20/D）：未确定

  8. 闪点（ºF）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（psi,55ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于75份水，几乎不溶于乙醇，溶液呈碱性

生物活性

• 描述: 尿酸钠是氧自由基的清除剂,是一种非常重要的抗氧化剂,有助于维持血压的稳定和抗氧化应激。尿酸钠可以去除活性氧物种(ROS),如单线态氧和过氧亚硝酸盐,抑制脂质过氧化[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点:

  Human Endogenous Metabolite

• 体外研究: 尿酸(400μM；48小时)保护Caco-2细胞免受吲哚美辛诱导的脂质过氧化[2]。用吲哚美辛和尿酸(200μmIND加400μmUA)联合处理细胞；与单独使用消炎痛培养的细胞相比,24小时)显著降低ROS水平。用吲哚美辛和尿酸(200μmIND加400μmUA)处理的Caco-2细胞的细胞活力；24小时)比单独使用吲哚美辛处理的细胞中的浓度高。尿酸通过其抗氧化活性对吲哚美辛诱导的肠细胞变化具有保护作用[2]。
• 体内研究: 尿酸(250mg/kg；p、 改善消炎痛引起的肠病[2]。在消炎痛诱导的肠病小鼠模型中,口服尿酸可减少回肠中ROS的积累[2]。动物模型：8周龄雄性C57BL/6J小鼠[2]剂量：250mg/kg体重给药：P.o.结果：当服用消炎痛的小鼠同时口服尿酸时,溃疡面积显著减少,呈尿酸剂量依赖性。
• 参考文献:

  [1]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017;32(11):1839-1845.

  [2]. Wang Q, et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375.

MSDS

Section 1. Chemical Product and Company Identification Uric Acid, Sodium Salt Common Name/ Trade Name Uric Acid, Sodium Salt Section 4. First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least Eye Contact 15 minutes. WARM water MUST be used. Get medical attention. In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove Skin Contact contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an Ingestion unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Not available. Flammable Limits These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated Special Remarks on temperatures Fire Hazards Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust Special Remarks on explosion hazard. Explosion Hazards Section 6. Accidental Release Measures Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading Small Spill water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on Large Spill the contaminated surface and allow to evacuate through the sanitary system. Uric Acid, Sodium Salt Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not Precautions breathe dust. Avoid contact with eyes. Wear suitable protective clothing. If you feel unwell, seek medical attention and show the label when possible. Keep away from incompatibles such as oxidizing agents. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Section 8. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below Engineering Controls recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE of a Large Spill handling this product. Not available. Exposure Limits Section 9. Physical and Chemical Properties Solid. (Crystalline powder.)Not available. Physical state andO dor appearance Not available. Taste 190.1 g/mole Molecular Weight White to yellowish. Color Not available. pH (1% soln/water) Not available. Boiling Point Not available. Melting Point Not available. Critical Temperature Not available. Specific Gravity Not applicable. Vapor Pressure Not available. Vapor Density Not available. Volatility Not available. Odor Threshold Not available. Water/Oil Dist. Coeff. Not available. Ionicity (in Water) Not available. Dispersion Properties Very slightly soluble in hot water. Solubility Section 10. Stability and Reactivity Data The product is stable. Stability Not available. Instability Temperature Conditions of Instability Excess heat, incompatible materials. Incompatibility with various Reactive with oxidizing agents. substances Not available. Corrosivity Uric Acid, Sodium Salt Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity Will not occur. Polymerization Section 11. Toxicological Information Inhalation. Ingestion. Routes of Entry LD50: Not available. Toxicity to Animals LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Not available. Special Remarks on Toxicity to Animals May cause adverse reproductive effects. Special Remarks on Chronic Effects on Humans Acute Potential Health Effects: Special Remarks on other Skin: May cause skin irritation. Toxic Effects on Humans Eyes: Causes eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Expected to be a low hazard. Section 12. Ecological Information Not available. Ecotoxicity Not available. BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Toxicity of the Products of Biodegradation Not available. Special Remarks on the Products of Biodegradation Section 13. Disposal Considerations Waste must be disposed of in accordance with federal, state and local environmental control Waste Disposal regulations. Section 14. Transport Information Not a DOT controlled material (United States). DO T Cl assi fi cati on Not applicable. Identification Not applicable. Special Provisions for Transport Uric Acid, Sodium Salt DO T (Pi ctograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Uric Acid, Sodium Salt Federal and State Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to California cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 214-838-1). Canada: Listed on Canadian Non-Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-2B: Material causing other toxic effects (TOXIC). Other Classifications R36- Irritating to eyes.S26- In case of contact with eyes, rinse DSCL (EEC) immediately with plenty of water and seek medical advice. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG(Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Uric Acid, Sodium Salt Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、 生殖毒性：小鼠生殖毒性试验TDLo：静脉注射，母鼠怀孕后8-10天，300gm/kg CHEMICAL IDENTIFICATION RTECS NUMBER : YU7062000 CHEMICAL NAME : Uric acid, monosodium salt CAS REGISTRY NUMBER : 1198-77-2 LAST UPDATED : 199701 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C5-H3-N4-O3.Na MOLECULAR WEIGHT : 190.11 WISWESSER LINE NOTATION : T56 BMVM FMVMVJ &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 300 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,289,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7188 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: YU7062000
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%