97207-47-1

• 常用中文名：甲异靛
• 常用英文名：Meisoindigo
• CAS号：97207-47-1
• 分子式：C₁₇H₁₂N₂O₂
• 分子量：276.289
• 相关类别： 原料药 抗肿瘤药 抗代谢类抗肿瘤药
• 发布时间：2018-04-04 08:00:00
• 更新时间：2026-06-30 14:51:26
• Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III)可诱导急性髓性白血病的凋亡和髓样分化。

名称

• 中文名: 甲异靛
• 英文名: (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one
• 中文别名: (E)-1-甲基-[3,3-联亚二氢吲哚基]-2,2-二酮; N-甲基-(3,3'-双-二氢吲哚)-2,2'-二酮; 甲异靛,10 MM DMSO 溶液; 抑制剂Meisoindigo; 异甲靛; 1-甲基-[3,3'-联吲哚基] -2,2'-二酮; 1-甲基-[3,3'-联吲哚啉亚基] -2,2'-二酮
• 英文别名: Meisoindigo, >=; 1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one; Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one; Meisoindigo, 10 mM in DMSO; 1-Methyl-[3,3'-biindolinylidene]-2,2'-dione; Natura-α; N-methylisoindigotin; Methylisoindigotin; Methylisoindigotin Meisoindigo; 3'-digallate; 2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl; 1-Methyl-1H,1'H-[3,3']biindolyliden-2,2'-dion; Meisoindigo(Natura; (e)-[3,3'-biindolinylidene]-2,2'-dione compound with methyl-l2-stannane (1:1); (E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione; Biindolene deriv.; (E)-1-methyl-1H,1'H-[3,3']biindolylidene-2,2'-dione; Meisoindigo //BP; 1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE; DIAN III; N-METHYLISOINDIGOTIN; NATURA-Α; 3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one; (E)-1-Methyl-1H,1'H-[3,3']biindolyliden-2,2'-dion; Theaflavine-3; HMS1593P16; 1-methyl-1H,1'H-[3,3']biindolylidene-2,2'-dione; Dian III; MEISOINDIGO; N-methylisoindigo; N-Methylisoindigotin; (3E)-1-Methyl-3-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1,3-dihydro-2H-indol-2-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 482.0±45.0 °C at 760 mmHg
• 熔点: 236-237ºC
• 分子式: C₁₇H₁₂N₂O₂
• 分子量: 276.289
• 闪点: 245.3±28.7 °C
• 精确质量: 276.089874
• PSA: 49.41000
• LogP: 1.53
• 外观性状: 固体;Orange to Brown to Dark red powder to crystal
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.698
• 储存条件: 室温

生物活性

• 描述: Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III)可诱导急性髓性白血病的凋亡和髓样分化。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Lee CC, et al. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk Lymphoma. 2010 May;51(5):897-905.

  [2]. Mingxin Z, et al. The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. J Chemother. 2008 Dec;20(6):728-33.

安全

• 海关编码: 2933990090

合成路线

59-48-3 2058-74-4 ~75% 97207-47-1

文献：Gholamzadeh, Parisa; Mohammadi Ziarani, Ghodsi; Badiei, Alireza; Abolhassani Soorki, Ali; Lashgari, Negar Research on Chemical Intermediates, 2013 , vol. 39, # 9 p. 3925 - 3936

91-56-5 ~% 97207-47-1

文献：Research on Chemical Intermediates, , vol. 39, # 9 p. 3925 - 3936

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%