63-75-2

• 常用中文名：槟榔碱
• 常用英文名：Arecoline
• CAS号：63-75-2
• 分子式：C₈H₁₃NO₂
• 分子量：155.19400
• 发布时间：2018-06-17 17:16:40
• 更新时间：2026-07-15 07:58:28
• Arecoline is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice.

名称

• 中文名: 槟榔碱
• 英文名: arecoline
• 中文别名: 甲基槟榔次碱; 游离槟榔碱; 槟榔碱(游离); 槟榔碱ecoline; 阿雷科林; 1-甲基-1,2,5,6-四氢吡啶-3-羧酸甲酯
• 英文别名: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; Methylecaidine; Arecolin; 3-Methoxycarbonyl-1-methyl-1,2,5,6-tetrahydropyridine; 3-Pyridinecboxylicacid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester; ecaidine Methyl Ester; ecoline ISO 9001：2015 REACH; Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-cboxylate; Methylarecaiden; methyl N-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; Methylarecaidin; ecaidin; methyl 1-methyl-3,6-dihydro-2H-pyridine-5-cboxylate; 1-Methyl-1,2,5,6-tertrahydro-pyridine-3-cboxylicacid methyl ester; 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecboxylic acid methyl; methyl 1,2,5,6-tetrahydro-1-methylnicotinate; Arekolin; ecolin; 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecboxylic Acid Methyl Ester; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; Arecoline base; Arecaidine methyl ester; Arecholine; 1-Methyl-1,2,5,6-tetrahydro-pyridine-3-cboxylic Acid Methyl Ester; Arecaline; Methyl ecaidin; NICOTINICACID,1,2,5,6-TETRAHYDRO-1-METHYL-,METHYLESTER; ECOLINE; methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate

物化性质

• 密度: 1.059g/cm3
• 沸点: 209ºC at 760mmHg
• 分子式: C₈H₁₃NO₂
• 分子量: 155.19400
• 闪点: 81.1ºC
• 精确质量: 155.09500
• PSA: 29.54000
• LogP: 0.35920
• 折射率: 1.483
• 储存条件: 室温，密闭，干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:3

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积:29.5

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:187

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QT2100000 CHEMICAL NAME : Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester CAS REGISTRY NUMBER : 63-75-2 BEILSTEIN REFERENCE NO. : 0123045 LAST UPDATED : 199703 DATA ITEMS CITED : 21 MOLECULAR FORMULA : C8-H13-N-O2 MOLECULAR WEIGHT : 155.22 WISWESSER LINE NOTATION : T6N CUTJ A1 CVO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Vascular - contraction (isolated tissues) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 2698 mg/kg/65W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : Micronucleus test TYPE OF TEST : Unscheduled DNA synthesis TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sister chromatid exchange TYPE OF TEST : Sperm Morphology MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 5 mg/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,501,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 37,141,1985

安全

• 海关编码: 2933399090

合成路线

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%