Arecoline

Modify Date: 2026-07-15 07:58:28

Arecoline structure	Common Name	Arecoline
	CAS Number	63-75-2	Molecular Weight	155.19400
	Density	1.059g/cm3	Boiling Point	209ºC at 760mmHg
	Molecular Formula	C₈H₁₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	81.1ºC

Use of Arecoline

Arecoline is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice.

Summary: Arecoline (Chinese name: 槟榔碱, CAS number: 63-75-2) has a molecular formula of C8H13NO2 and a molecular weight of 155.19400. It is used as a ganglionic stimulant and a vermifuge, especially in veterinary practice. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	arecoline
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.059g/cm3
Boiling Point	209ºC at 760mmHg
Molecular Formula	C₈H₁₃NO₂
Molecular Weight	155.19400
Flash Point	81.1ºC
Exact Mass	155.09500
PSA	29.54000
LogP	0.35920
Index of Refraction	1.483
InChIKey	HJJPJSXJAXAIPN-UHFFFAOYSA-N
SMILES	COC(=O)C1=CCCN(C)C1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2100000

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester

CAS REGISTRY NUMBER :: 63-75-2

BEILSTEIN REFERENCE NO. :: 0123045

LAST UPDATED :: 199703

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C8-H13-N-O2

MOLECULAR WEIGHT :: 155.22

WISWESSER LINE NOTATION :: T6N CUTJ A1 CVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Vascular - contraction (isolated tissues)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 2698 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,501,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 37,141,1985

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933399090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:300-08-3 Arecoline hydro... CAS#:117912-07-9 (3R,4S)-methyl ... CAS#:4685-10-3 Iodonicot CAS#:86343-57-9 N-Methyl-3-carb...
CAS#:499-04-7 Arecaidine CAS#:67-56-1 Methanol CAS#:37673-66-8 ethyl 4-hydroxy... CAS#:25012-72-0 Ethyl 1-methyl-...
CAS#:6315-60-2 N,N-DI-(BETA-CA...
DownStream 10
CAS#:499-04-7 Arecaidine CAS#:5809-87-0 3-Pyridinecarbo... CAS#:214335-16-7 (3S,4S)-3,4-BIS... CAS#:26070-52-0 N,N-diethyl-1-m...
CAS#:169105-89-9 5-epi-Isofagomine CAS#:1142-19-4 bis(4-chlorophe... CAS#:117912-07-9 (3R,4S)-methyl ... CAS#:86447-11-2 1-Boc-1,2,5,6-t...
CAS#:102206-67-7 (1-methyl-3,6-d... CAS#:1690-72-8 Methyl 1-methyl...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Effective concentration of compound for the agonistic activity on guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL883445

Name: Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M1
External Id: CHEMBL746423

Name: The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M to...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL741873

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 20...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449006

Name: Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of ra...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL747587

Name: Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine recep...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL747588

Name: Ability to stimulate phosphoinositol metabolism was examined in the rat cerebral cort...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL795511

Name: Binding affinity against muscarinic acetylcholine receptor from rat brain crude membr...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL747589

Total 553, Current Page 1 of 56

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate

Arekolin

Arecolin

Arecholine

methyl N-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

3-Methoxycarbonyl-1-methyl-1,2,5,6-tetrahydropyridine

Arecaline

Methylarecaiden

methyl 1,2,5,6-tetrahydro-1-methylnicotinate

Methylarecaidin

Arecoline base

Arecaidine methyl ester

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of arecoline?

A: Related downstream products(CAS) of arecoline: 499-04-7;5809-87-0;214335-16-7;26070-52-0;169105-89-9;1142-19-4;117912-07-9;86447-11-2;102206-67-7;1690-72-8.

Q: What are the upstream materials of arecoline?

A: Related upstream materials(CAS) of arecoline: 300-08-3;117912-07-9;4685-10-3;86343-57-9;499-04-7;67-56-1;37673-66-8;25012-72-0;6315-60-2.

Q: What is the boiling point of arecoline?

A: Boiling point of arecoline is 209ºC at 760mmHg.

Q: What is the CAS number of arecoline?

A: CAS number of arecoline is 63-75-2.

Q: What is the polar surface area (PSA) of arecoline?

A: Polar surface area (PSA) of arecoline is 29.54000.

Q: What is the molecular weight of arecoline?

A: Molecular weight of arecoline is 155.19400.

Q: What is the molecular formula of arecoline?

A: Molecular formula of arecoline is C8H13NO2.

Q: What are the uses of arecoline?

A: Main uses of arecoline: Arecoline is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice.

Q: What is the LogP of arecoline?

A: LogP of arecoline is 0.35920.

Q: What is the English name of arecoline?

A: The English name of arecoline is arecoline.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Arecoline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Arecoline

Use of Arecoline

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Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.