137973-76-3

• 常用中文名：N-[4-[(7-氯-2,3,4,5-四氢-5-氧代-1H-1-苯并氮杂卓-1-基)羰基]-3-甲基苯基]-2-甲基苯甲酰胺
• 常用英文名：N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
• CAS号：137973-76-3
• 分子式：C₂₆H₂₃ClN₂O₃
• 分子量：446.925
• 发布时间：2018-12-25 06:21:20
• 更新时间：2026-06-30 07:54:29

名称

• 中文名: 7-氯-1-[2-甲基-4-[(2-甲基苯甲酰)氨基]苯甲酰基]-5-氧代-2,3,4,5-四氢-1H-1-苯并氮杂卓
• 英文名: N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
• 中文别名: 托伐普坦杂质5(DM-21826); 托伐普坦04; 托尔瓦普坦杂质5; 7-氯-1-[2-甲基-4-[(2-甲基苯甲酰)氨基]苯甲酰; 托伐普坦中间体N-1; N-(4-(7-氯-5-氧代-2,3,4,5-四氢-1H-苯并[B]氮杂-1-羰基)-3-甲基苯基)-2-甲基苯甲酰胺; N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazin-1-yl)cbonyl]-3-methylphenyl]-2-methylbenzamide CAS号: 137-3; N-[4-[(7-CHLORO-2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZIN-1-YL)CBONYL]-3-METHYLPHENYL]-2-METHYLBENZAMIDE CAS号:137-3; N-(4-(7-氯-5-氧代-2,3,4,5-四氢-1H-苯并[B]氮杂卓-1-羰基)-3-甲基苯基)-2-甲基苯甲酰胺; N-[4-[(7-氯-2,3,4,5-四氢-5-氧代-1H-1-苯并氮杂卓-1-基)羰基]
• 英文别名: 5-oxo-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra-hydro-1H-benzoazepine; Dehydrotolvaptan; N-[4-[(7- chloro -2,3,4,5- tetrahydro -5- oxo -1H-1- benzoazine -1- yl) carbonyl ]-3- methylphenyl ]-2- methylbenzamide; 5-Dehydro Tolvaptan; 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox; N-[4-[7-Chloro-2,3,4,5-Tetrahydro-5-oxo-1H-1-Benzazine-1-yl)carbonyl]-3-MethylPhenyl]-2-MethylBenzamide; N-[4-[(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzazin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide; N-{4-[(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide; Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazin-1-yl)carbonyl]-3-methylphenyl]-2-methyl; N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; Tolvaptan Intermediate; 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazine; N-[4-[(7-CHLORO-2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL]-3-METHYLPHENYL]-2-METHYLBENZAMIDE; 7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one; N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide; N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azine-1-carbonyl)-3-methylphenyl)-2-methylbe; N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azine-1-carbonyl)-3-Methylphenyl)-2-MethylbenzaMide; N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azine-1-carbonyl)-3-methylphenyl)-2-methy; 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine; Tolvaptan Impurity 2; 5-oxo-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine; Tolvaptan 5-Oxo Analog; N-[4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; Tolvaptan impurity 5 (DM-21826); N-(4-(7-chloro-5-oxo-2,3,4-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide; N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 593.2±50.0 °C at 760 mmHg
• 分子式: C₂₆H₂₃ClN₂O₃
• 分子量: 446.925
• 闪点: 312.6±30.1 °C
• 精确质量: 446.139709
• PSA: 66.48000
• LogP: 5.08
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.655
• 储存条件: 室温

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%