502-37-4

• 常用中文名：HYPOGLYCINB
• 常用英文名：HYPOGLYCINB
• CAS号：502-37-4
• 分子式：C₁₂H₁₈N₂O₅
• 分子量：270.28200
• 发布时间：2016-06-28 05:07:45
• 更新时间：2024-01-12 16:21:07

名称

• 英文名: L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
• 英文别名: Hypoglyin-B; (S)-2-L-alanylamino-butyric acid; (S)-2-L-Alanylamino-buttersaeure; L-2-(L-2-Amino-propionylamino)-buttersaeure; N-L-Alanyl-L-2-amino-buttersaeure

物化性质

• 密度: 1.33g/cm3
• 沸点: 592.8ºC at 760mmHg
• 分子式: C₁₂H₁₈N₂O₅
• 分子量: 270.28200
• 闪点: 312.3ºC
• 精确质量: 270.12200
• PSA: 133.21000
• LogP: 1.25470
• 折射率: 1.562

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AY6330000 CHEMICAL NAME : Alanine, N-L-gamma-glutamyl-3-(methylenecyclopropyl)- CAS REGISTRY NUMBER : 502-37-4 BEILSTEIN REFERENCE NO. : 3162184 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C12-H18-N2-O5 MOLECULAR WEIGHT : 270.32 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Endocrine - hypoglycemia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intrauterine DOSE : 500 ug/kg SEX/DURATION : female 14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,246,1971

合成路线

406-09-7 ~% 502-37-4

文献：Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

45214-61-7 ~% 502-37-4

文献：Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

156-56-9 ~% 502-37-4

文献：Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

80514-73-4 ~% 502-37-4

文献：Hassall; John Tetrahedron Letters, 1959 , # 3 p. 7

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