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502-37-4

502-37-4 structure
502-37-4 structure
  • Name: HYPOGLYCINB
  • Chemical Name: L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
  • CAS Number: 502-37-4
  • Molecular Formula: C12H18N2O5
  • Molecular Weight: 270.28200
  • Create Date: 2016-06-28 05:07:45
  • Modify Date: 2024-01-12 16:21:07

Name L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
Synonyms Hypoglyin-B
(S)-2-L-alanylamino-butyric acid
(S)-2-L-Alanylamino-buttersaeure
L-2-(L-2-Amino-propionylamino)-buttersaeure
N-L-Alanyl-L-2-amino-buttersaeure
Density 1.33g/cm3
Boiling Point 592.8ºC at 760mmHg
Molecular Formula C12H18N2O5
Molecular Weight 270.28200
Flash Point 312.3ºC
Exact Mass 270.12200
PSA 133.21000
LogP 1.25470
Index of Refraction 1.562

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY6330000
CHEMICAL NAME :
Alanine, N-L-gamma-glutamyl-3-(methylenecyclopropyl)-
CAS REGISTRY NUMBER :
502-37-4
BEILSTEIN REFERENCE NO. :
3162184
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H18-N2-O5
MOLECULAR WEIGHT :
270.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Endocrine - hypoglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intrauterine
DOSE :
500 ug/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,246,1971

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502-37-4 structure

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

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502-37-4 structure

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

~%

502-37-4 structure

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

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502-37-4 structure

502-37-4

Literature: Hassall; John Tetrahedron Letters, 1959 , # 3 p. 7
Precursor  3

DownStream  0