1111177-30-0

• 常用中文名：缬沙坦乙酯
• 常用英文名：Valsartan Ethyl Ester
• CAS号：1111177-30-0
• 分子式：C₂₆H₃₃N₅O₃
• 分子量：463.572
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 血管紧张素受体
• 发布时间：2018-06-23 16:10:42
• 更新时间：2026-07-24 09:12:15
• Valsartan Ethyl Ester 是 Valsarta (CGP-48933) 的杂质。Valsartan 是用于治疗高血压和心力衰竭的血管紧张素 II 受体拮抗剂。

名称

• 中文名: 缬沙坦杂质 01
• 英文名: Ethyl N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-L-valinate
• 中文别名: 缬沙坦杂质Ⅱ; 缬沙坦杂质21; 缬沙坦; N-戊酰基-N-[2'-(1H-四唑-5-基)[1,1'-联苯基]-4-基甲基]-L-缬氨酸乙酯; 缬沙坦杂质; N-(1-氧代戊基)-N-[[2'-(2H-四唑-5-基)[1,1'-联苯]-4-基]甲基]-L-缬氨酸乙酯; 乙基正-((2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-正戊酰基-1-缬氨酸; 原研
• 英文别名: Valstan impurities30; ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'- biphenyl]-4-yl)methyl)-N-pentanoyl- L-valinate; Valstan impurity 2/Valstan Ethyl Ester/Ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-N-pentanoyl-L-valinate; L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester; N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine ethyl ester; Valstan-2; Valstan Acid Ethyl Ester; (S)-ethyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate; ethyl N-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N- pentanoylvalinate; Valsartan Impurity 18; Valstan Impurity: N-(1-Oxopentyl)-N-[[2`-(2H-tetrazol-5-yl)[1,1`-biphenyl]-4-yl]methyl]-L-valine Ethyl Ester (Valstan ethyl ester); (S)-ethyl 2-(N-((2'-(1H-tetrazol-5-yl); Ethyl N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-ylmethyl]-L-valinate; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester; Valstan Ethyl EsterQ: What is Valstan Ethyl Ester Q: What is the CAS Number of Valstan Ethyl Ester Q: What is the storage condition of Valstan Ethyl Ester Q: What e the applications of Valstan Ethyl Ester; ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-N-pentanoyl-L-valinate; EthylN-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate; Valstan Impurity E

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 655.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₃₃N₅O₃
• 分子量: 463.572
• 闪点: 350.4±34.3 °C
• 精确质量: 463.258331
• LogP: 5.83
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.562

生物活性

• 描述: Valsartan Ethyl Ester 是 Valsarta (CGP-48933) 的杂质。Valsartan 是用于治疗高血压和心力衰竭的血管紧张素 II 受体拮抗剂。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
• 参考文献:

  [1]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80.