591778-70-0

• 常用中文名：盐酸CP-640186
• 常用英文名：CP-640186 hydrochloride
• CAS号：591778-70-0
• 分子式：C₃₀H₃₆ClN₃O₃
• 分子量：522.078
• 相关类别： 信号通路 代谢酶/蛋白酶 乙酰辅酶A羧化酶
• 发布时间：2018-02-11 08:00:00
• 更新时间：2026-07-01 17:53:20
• CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。

名称

• 中文名: 盐酸CP-640186
• 英文名: 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
• 中文别名: 抑制剂-640186 hydrochloride; 640186 盐酸盐; (R)-蒽-9-基(3-吗啉-4-羰基)-[1,4'-联哌啶]-1'-基)酮盐酸盐; 盐酸-640186,10 MM DMSO 溶液; 盐酸-640186
• 英文别名: 640186 (hydrochloride); 640186 hydrochloride, 10 mM in DMSO; (R)-Anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone hydrochloride; 640186 hydrochloride, >=; HG2,muscle fatty acid oxidation,Inhibitor,640186,640186,C2C12,-640186,human fibroblasts,H460,muscle strips,640186 hydrochloride,inhibit,ACC, Acetyl Coenzyme A Cboxylase,Acetyl-CoA Cboxylase,640186 hydrochloride; (3R)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-c bonyl)-1,4'-bipiperidine hydrochloride; 640186 HCl; CP-640186 (hydrochloride); Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-, hydrochloride (1:1)

物化性质

• 分子式: C₃₀H₃₆ClN₃O₃
• 分子量: 522.078
• 精确质量: 521.244507
• 储存条件: 2-8℃

生物活性

• 描述: CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 乙酰辅酶A羧化酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

  [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.