121577-32-0

• 常用中文名：加替沙星盐酸盐
• 常用英文名：Gatifloxacin hydrochloride
• CAS号：121577-32-0
• 分子式：C₁₉H₂₃ClFN₃O₄
• 分子量：411.855
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-01-28 09:47:27
• 更新时间：2024-02-02 17:32:12
• Gatifloxacin盐酸盐是第四代氟喹诺酮类抗生素，能抑制细菌的DNA旋转酶和拓扑异构酶IV。

名称

• 中文名: 加替沙星盐酸盐
• 英文名: Gatifloxacin hydrochloride
• 英文别名: MFCD09838901; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1); 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrochloride (1:1); 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1); Gatifloxacin (hydrochloride)

物化性质

• 分子式: C₁₉H₂₃ClFN₃O₄
• 分子量: 411.855
• 精确质量: 411.136108
• 储存条件: 2-8℃

生物活性

• 描述: Gatifloxacin盐酸盐是第四代氟喹诺酮类抗生素,能抑制细菌的DNA旋转酶和拓扑异构酶IV。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
  天然产物 >> 生物碱
• 参考文献:

  [1]. Fukuda, H., S. Hori, and K. Hiramatsu, Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. A

  [2]. Jensen, H., et al., Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther, 2005. 21(1): p. 36-43.

  [3]. Cheung, O., et al., Gatifloxacin-induced hepatotoxicity and acute pancreatitis. Ann Intern Med, 2004. 140(1): p. 73-4.

  [4]. Fteha, A., et al., Gatifloxacin induced torsades de pointes. Pacing Clin Electrophysiol, 2004. 27(10): p. 1449-50.