120298-73-9

• 常用中文名：甲状旁腺激素相关蛋白
• 常用英文名：pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt
• CAS号：120298-73-9
• 分子式：C₂₀₇H₃₃₄N₆₆O₅₈
• 分子量：4675
• 相关类别： 信号通路 表观遗传学 PKC
• 发布时间：2018-06-18 01:56:13
• 更新时间：2026-07-07 20:03:11
• pTH相关蛋白(1-40)(人、小鼠、大鼠)通过PTHR1受体和PKCα/β信号通路刺激大鼠肠细胞的钙摄取。pTH相关蛋白(1-40)上调甲状旁腺激素1受体(PTHR1)蛋白、四种跨细胞钙转运蛋白、潜在香兰素成员6(TRPV6)、钙结合蛋白D9K(CaBP-D9K)、钠钙交换蛋白1(NCX1)和质膜钙ATP酶1(PMCA1)[1]。

名称

• 中文名: 甲状旁腺激素相关蛋白
• 英文名: (4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-4-carboxy-butanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxo-pentanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxy-propanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-carboxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-pentanoyl]amino]propanoyl]amino]-5-[[(1S,2S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[[(1S)-3-carboxy-1-[[(1S,2S)-1-[[(1S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-methyl-butyl]carbamoyl]propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid
• 中文别名: 恶性因子 人的高钙血症; 人恶性肿瘤高血钙症因子; 甲状旁腺激素样腺苷酸环化酶刺激蛋白
• 英文别名: Human PTHrP; PTH-LIKE ADENYLATE CYCLASE STIMULATING PROTEIN; Hypercalcemia of malignancy factor human >= (HPLC); Pathyroid hormone-related protein , PTH-Like Adenylate Cyclase Stimulating Protein, PTHrP , Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-g-g-g-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-g-Ala-Thr-Ser; HypercalceMia of Malignancy Factor (huMan, Mouse, rat); PTH-RELATED PROTEIN , HUMAN; hypercalcemia of malignancy factor-40; HYPERCALCEMIA OF MALIGNANCY FACTOR-40 HUMAN; ALA-VAL-SER-GLU-HIS-GLN-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-G-G-G-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-GLU-ILE-G-ALA-THR-SER: AVSEHQLLHDKGKSIQDRRFFLHHLIAEIHTAEIRATS; PTHrP; HYPERCALCEMIA MALIGNANCY FACTOR; HYPERCALCEMIA OF MALIGNANCY FACTOR (HUMAN, RAT); pTH-Related Protein (human, mouse, rat); PTH-RELATED PTIDE; H-ALA-VAL-SER-GLU-HIS-GLN-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-G-G-G-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-GLU-ILE-G-ALA-THR-SER-OH; ala-val-ser-glu-his-gln-leu-leu-his-asp-lys-gly-lys-ser-ile-gln-asp-leu-g-g-g-phe-phe-leu-his-his-leu-ile-ala-glu-ile-his-thr-ala-glu-ile-g-ala-thr-ser; AVSEHQLLHDKGKSIQDRRFFLHHLIAEIHTAEIRATS; PTH-RELATED PROTEIN (HUMAN, RAT)

物化性质

• 分子式: C₂₀₇H₃₃₄N₆₆O₅₈
• 分子量: 4675
• 精确质量: 4674.5282025

生物活性

• 描述: pTH相关蛋白(1-40)(人、小鼠、大鼠)通过PTHR1受体和PKCα/β信号通路刺激大鼠肠细胞的钙摄取。pTH相关蛋白(1-40)上调甲状旁腺激素1受体(PTHR1)蛋白、四种跨细胞钙转运蛋白、潜在香兰素成员6(TRPV6)、钙结合蛋白D9K(CaBP-D9K)、钠钙交换蛋白1(NCX1)和质膜钙ATP酶1(PMCA1)[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> PKC
  研究领域 >> 内分泌
  信号通路 >> TGF-beta/Smad 信号通路 >> PKC

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport