pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt

更新时间：2024-01-21 17:19:18

pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt结构式	常用名	pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt	英文名	pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt
	CAS号	120298-73-9	分子量	N/A
	密度	N/A	沸点	N/A
	分子式	C₂₀₇H₃₃₄N₆₆O₅₈	熔点	N/A
	MSDS	美版	闪点	N/A

用途

pTH相关蛋白(1-40)(人、小鼠、大鼠)通过PTHR1受体和PKCα/β信号通路刺激大鼠肠细胞的钙摄取。pTH相关蛋白(1-40)上调甲状旁腺激素1受体(PTHR1)蛋白、四种跨细胞钙转运蛋白、潜在香兰素成员6(TRPV6)、钙结合蛋白D9K(CaBP-D9K)、钠钙交换蛋白1(NCX1)和质膜钙ATP酶1(PMCA1)[1]。

英文名	(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-4-carboxy-butanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxo-pentanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxy-propanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-carboxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-pentanoyl]amino]propanoyl]amino]-5-[[(1S,2S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[[(1S)-3-carboxy-1-[[(1S,2S)-1-[[(1S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-methyl-butyl]carbamoyl]propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid

英文名

(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-4-carboxy-butanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxo-pentanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxy-propanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-carboxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-pentanoyl]amino]propanoyl]amino]-5-[[(1S,2S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[[(1S)-3-carboxy-1-[[(1S,2S)-1-[[(1S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-methyl-butyl]carbamoyl]propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid

描述	pTH相关蛋白(1-40)(人、小鼠、大鼠)通过PTHR1受体和PKCα/β信号通路刺激大鼠肠细胞的钙摄取。pTH相关蛋白(1-40)上调甲状旁腺激素1受体(PTHR1)蛋白、四种跨细胞钙转运蛋白、潜在香兰素成员6(TRPV6)、钙结合蛋白D9K(CaBP-D9K)、钠钙交换蛋白1(NCX1)和质膜钙ATP酶1(PMCA1)[1]。
相关类别	信号通路 >> 表观遗传学 >> PKC 研究领域 >> 内分泌信号通路 >> TGF-beta/Smad 信号通路 >> PKC

分子式	C₂₀₇H₃₃₄N₆₆O₅₈

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV40-immortalized breast epithelial cells.

J. Bone Miner Res. 15 , 2129-2139, (2000)

Parathyroid hormone-related protein (PTHrP) is the main mediator of humoral hypercalcemia of malignancy (HHM) and it is produced by many tumors, including breast cancers. Breast epithelial cells as we...

Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

Cancer Res. 57 , 3194-3199, (1997)

Humoral hypercalcemia of malignancy results from the effects of tumor-produced factors on bone, kidney, and intestine that disrupt normal calcium homeostasis. Although parathyroid hormone-related prot...

Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.

Domest. Anim. Endocrinol. 8 , 499-507, (1991)

The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and ...

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：恶性因子 1-40 人的高钙血症
纯度：95.0%
规格：
联系人：徐经理
联系电话：13311869306

南京肽业生物科技有限公司
江苏省南京市六合区
产品名：pTH-Related Protein (1-40) (human, mouse, rat)
纯度：98.0%
规格：10g/100g/1kg/10kg
联系人：滕经理
联系电话：17372270798

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pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt

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