157884-74-7

• 常用中文名：Amyloid β-Protein (3-42) ammonium salt
• 常用英文名：Amyloid β-Protein (3-42) ammonium salt
• CAS号：157884-74-7
• 分子式：C₁₉₆H₃₀₁N₅₃O₅₆S
• 分子量：
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-06-09 06:18:05
• 更新时间：2024-01-13 10:33:08
• 淀粉样β-蛋白(3-42)是Pyr肽的前体。焦谷氨酸修饰的Aβ(pEAβ)(3-42)是阿尔茨海默病淀粉样蛋白模板阻断的核心。pEAβ(3-42)加速了Aβ(1-42)的聚集,而Aβ(1-4 2)显著减缓了pEAβ的一次和二次成核[1]。

名称

• 英文名: (4S)-4-amino-5-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-4-amino-1-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-5-amino-1-[[2-[[(1S)-2-[[(1S,2S)-1-[[(1S,2S)-1-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[2-[[2-[[(1S)-1-[[(1S)-1-[[(1S,2S)-1-[[(1S)-1-carboxyethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]carbamoyl]-4-oxo-butyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-carboxy-propyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-benzyl-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

物化性质

• 分子式: C₁₉₆H₃₀₁N₅₃O₅₆S

生物活性

• 描述: 淀粉样β-蛋白(3-42)是Pyr肽的前体。焦谷氨酸修饰的Aβ(pEAβ)(3-42)是阿尔茨海默病淀粉样蛋白模板阻断的核心。pEAβ(3-42)加速了Aβ(1-42)的聚集,而Aβ(1-4 2)显著减缓了pEAβ的一次和二次成核[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病