150646-45-0

• 常用中文名：(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt
• 常用英文名：(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt
• CAS号：150646-45-0
• 分子式：C₁₅₉H₂₆₇N₄₉O₄₃
• 分子量：3553.124
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 CRFR
• 发布时间：2018-06-23 11:10:02
• 更新时间：2024-01-19 11:44:59
• (D-Phe12,Nle21,38,α-Me-Leu37)-CRF(12-41)(人,大鼠)是CRF拮抗剂。(D-Phe12,Nle21,38,α-Me-Leu37)-CRF(12-41)(人,大鼠)阻止IL-1a诱导的促黄体生成素(LH)抑制[1]。

名称

• 英文名: D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-L-isoleucinamide
• 英文别名: D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-gluta
 minyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-L-isoleucinamide; L-Isoleucinamide, D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucy
 l-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₅₉H₂₆₇N₄₉O₄₃
• 分子量: 3553.124
• 精确质量: 3551.021240
• LogP: -4.34
• 折射率: 1.644

生物活性

• 描述: (D-Phe12,Nle21,38,α-Me-Leu37)-CRF(12-41)(人,大鼠)是CRF拮抗剂。(D-Phe12,Nle21,38,α-Me-Leu37)-CRF(12-41)(人,大鼠)阻止IL-1a诱导的促黄体生成素(LH)抑制[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR
• 参考文献:

  [1]. Feng YJ, et al. An inhibitory effects of interleukin-1a on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology. 1991 Apr;128(4):2077-82.