中文名 | [D-Trp34]-神经肽Y三氟乙酸盐 |
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英文名 | (4S)-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-oxo-butanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(1S)-1-[[(1S)-2-[(2S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2S)-1-[[(1S)-3-amino-1-[[(1S)-1-[[(1S,2S)-1-[[(1S,2R)-1-[[(1S)-1-[[(1R)-2-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-hydroxy-3-oxo-propyl]carbamoyl]-4-hydroxy-4-oxo-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]carbamoyl]-3-hydroxy-3-oxo-propyl]amino]-5-oxo-pentanoic acid |
描述 | [D-Trp34]-Neuropeptide Y 是有效的,选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y 在 NPY Y1,Y2,Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y 明显增加大鼠的食物摄入量。 |
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相关类别 | |
靶点 |
NPY Y5 receptor |
体外研究 | [D-Trp34]-神经肽Y在CHO细胞中的pKi值为6.49、5.43、7.08、7.53、6.55、5.95、6.85、7.41,在CHO细胞中的pKi值为6.49、5.43、7.08、7.53、6.55、5.95、6.85、7.41。[D-Trp34]-神经肽Y的pEC50值在CHO细胞中为6.44,<6,6.28,7.82,在HEK-293细胞中为rY4,rY5[1]。 |
体内研究 | 【D-Trp34】-神经肽Y(0、8和16μg/只大鼠;I.C.V)在雄性Zucker大鼠注射16μg剂量后1 h后,对瘦肉和肥胖大鼠的食物摄取有相同程度的刺激作用[2]。 |
参考文献 |
分子式 | C196H289N55O56 |
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分子量 | 4311.77 |
储存条件 | -20°C |