[D-Trp34]-Neuropeptide Y

• 常用名: [D-Trp34]-Neuropeptide Y
• 英文名: [D-Trp34]-Neuropeptide Y
• CAS号: 153549-84-9
• 分子量: 4311.77
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉₆H₂₈₉N₅₅O₅₆
• 熔点: N/A
• 闪点: N/A

[D-Trp34]-Neuropeptide Y用途

[D-Trp34]-Neuropeptide Y 是有效的,选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y 在 NPY Y1,Y2,Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y 明显增加大鼠的食物摄入量。

[D-Trp34]-Neuropeptide Y名称

• 中文名: [D-Trp34]-神经肽Y三氟乙酸盐
• 英文名: (4S)-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]-4-oxo-butanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(1S)-1-[[(1S)-2-[(2S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2S)-1-[[(1S)-3-amino-1-[[(1S)-1-[[(1S,2S)-1-[[(1S,2R)-1-[[(1S)-1-[[(1R)-2-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-hydroxy-3-oxo-propyl]carbamoyl]-4-hydroxy-4-oxo-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]carbamoyl]-3-hydroxy-3-oxo-propyl]amino]-5-oxo-pentanoic acid

[D-Trp34]-Neuropeptide Y生物活性

• 描述: [D-Trp34]-Neuropeptide Y 是有效的,选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y 在 NPY Y1,Y2,Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y 明显增加大鼠的食物摄入量。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
• 靶点实验:

  NPY Y5 receptor

• 体外研究: [D-Trp34]-神经肽Y在CHO细胞中的pKi值为6.49、5.43、7.08、7.53、6.55、5.95、6.85、7.41,在CHO细胞中的pKi值为6.49、5.43、7.08、7.53、6.55、5.95、6.85、7.41。[D-Trp34]-神经肽Y的pEC50值在CHO细胞中为6.44,<6,6.28,7.82,在HEK-293细胞中为rY4,rY5[1]。
• 体内研究: 【D-Trp34】-神经肽Y(0、8和16μg/只大鼠；I.C.V)在雄性Zucker大鼠注射16μg剂量后1 h后,对瘦肉和肥胖大鼠的食物摄取有相同程度的刺激作用[2]。
• 参考文献:

  [1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.

  [2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y₅ receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.

[D-Trp34]-Neuropeptide Y物理化学性质

• 分子式: C₁₉₆H₂₈₉N₅₅O₅₆
• 分子量: 4311.77
• InChIKey: YZSPVSFRBZGLIZ-QIJQHHJSSA-N
• SMILES: CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C1CCCN1C(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccc(O)cc1)C(N)=O)C(C)O)C(C)CC
• 储存条件: -20°C