66487-95-4

• 常用中文名：Dimethyl fumarate D6
• 常用英文名：Dimethyl fumarate d6
• CAS号：66487-95-4
• 分子式：C₆H₂D₆O₄
• 分子量：150.162290668
• 相关类别： 信号通路 NF-κB信号通路 KEAP1-Nrf2
• 发布时间：2018-07-08 22:24:20
• 更新时间：2024-01-05 18:34:20
• Dimethyl fumarate D6 是 Dimethyl fumarate 的氘代标记物。Dimethyl fumarate 是一种 Nrf2 激活剂,能够诱导上调抗氧化基因的表达。

名称

• 英文名: Dimethyl fumarate d6

物化性质

• 分子式: C₆H₂D₆O₄
• 分子量: 150.162290668

生物活性

• 描述: Dimethyl fumarate D6 是 Dimethyl fumarate 的氘代标记物。Dimethyl fumarate 是一种 Nrf2 激活剂,能够诱导上调抗氧化基因的表达。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Albrecht P, et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation. 2012 Jul 7;9:163.

  [2]. Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26.

  [3]. Meili-Butz S, et al. Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats. Eur J Pharmacol. 2008 May 31;586(1-3):251-8.

  [4]. Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25.

  [5]. Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40.

  [6]. Li Y, et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102.