66755-19-9

66755-19-9结构式
66755-19-9结构式

化源商城直购

中文名 海藻糖6-山ate酸
英文名 Trehalose 6-behenate
描述 Trehalose 6-behenate 是一种 Th1/Th17 疫苗佐剂。
相关类别
靶点

Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].

参考文献

[1]. Stocker BL, et al. On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner. Chembiochem. 2014 Feb 10;15(3):382-8.

分子式 C34H64O12
分子量 664.86