海藻糖6-山ate酸

• 常用名: 海藻糖6-山ate酸
• 英文名: Trehalose 6-behenate
• CAS号: 66755-19-9
• 分子量: 664.86
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₆₄O₁₂
• 熔点: N/A
• 闪点: N/A

海藻糖6-山ate酸用途

Trehalose 6-behenate 是一种 Th1/Th17 疫苗佐剂。

海藻糖6-山ate酸名称

• 中文名: 海藻糖6-山ate酸
• 英文名: Trehalose 6-behenate

海藻糖6-山ate酸生物活性

• 描述: Trehalose 6-behenate 是一种 Th1/Th17 疫苗佐剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点:

  Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].

• 参考文献:

  [1]. Stocker BL, et al. On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner. Chembiochem. 2014 Feb 10;15(3):382-8.

海藻糖6-山ate酸物理化学性质

• 分子式: C₃₄H₆₄O₁₂
• 分子量: 664.86