1374248-81-3

• 常用中文名：阿托吉泮
• 常用英文名：Atogepant
• CAS号：1374248-81-3
• 分子式：C₂₉H₂₃F₆N₅O₃
• 分子量：603.515
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 CGRP受体
• 发布时间：2020-01-12 09:01:32
• 更新时间：2026-07-14 09:11:12
• 一种有效的,选择性的和口服的CGRP受体拮抗剂,用于预防偏头痛。偏头痛3期临床

名称

• 中文名: 阿托吉泮
• 英文名: atogepant
• 中文别名: (S)-N-((3S,5S,6R)-6-甲基-2-氧代-1-(2,2,2-三氟乙基)-5-(2,3,6-三氟苯基)哌啶-3-基)-2'-氧代-1',2',5,7-四氢螺[环戊二烯并[b]吡啶-6,3'-吡咯并[2,3-b]吡啶]-3-甲酰胺; 阿托吉泮杂质37; UBROGANT阿托吉泮; (S)-N-((3S,5S,6R)-6-甲基-2-氧代-1-(2,2,2-三氟乙基)-5-(2,3,6-三氟苯基)哌啶-3-基)-2'-氧代-1',2',5,7-四氢螺[环戊二烯并[B]吡啶-6,3'-吡咯并[2,3-B]吡啶]-3-甲酰胺; (S)-N-[(3S,5S,6R)-6-甲基-2-氧代-1-(2,2,2-三氟乙基)-5-(2,3,6-三氟苯基)哌啶-3-基]-2'-氧代-1',2',5,7-四氢螺[环戊并[b]吡啶-6,3'-吡咯并[2,3-b]吡啶]-2-甲酰胺
• 英文别名: AGN-241689）; MK8031. Atogant; (S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-cboxamide; 7CRV8RR151; (S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-cboxamid; Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-cboxamide, 1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-, (3'S); (S)-N-((3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-cboxamide; MK-8031; (6S)-N-[(3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide; (S)-N-[(3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-2-cboxamide; Atogant Monohydrate; Atogant API; (3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-cboxamide; atogepantum; (S)-1'-(tert-butyl)-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-cboxamide; (3'S)-1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-Spiro[6H

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 693.9±55.0 °C at 760 mmHg
• 分子式: C₂₉H₂₃F₆N₅O₃
• 分子量: 603.515
• 闪点: 373.5±31.5 °C
• 精确质量: 603.170532
• LogP: 4.37
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.624

生物活性

• 描述: 一种有效的,选择性的和口服的CGRP受体拮抗剂,用于预防偏头痛。偏头痛3期临床
• 参考文献: References View Related Products by Target CGRP Receptor Migraine