4696-76-8

• 常用中文名：卡那霉素 B
• 常用英文名：Bekanamycin
• CAS号：4696-76-8
• 分子式：C₁₈H₃₇N₅O₁₀
• 分子量：483.514
• 相关类别： 原料药 抗生素类药物 氨基糖苷类药
• 发布时间：2018-06-27 09:41:45
• 更新时间：2024-01-02 09:42:00
• Bekanamycin是一种氨基糖苷类抗生素。

名称

• 中文名: 卡那霉素 B
• 英文名: kanamycin B
• 中文别名: 卡那霉素B
• 英文别名: 4,6-Diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside; aminodeoxykanamycin; NK-1006; α-D-Glucopyranoside, (1S,2R,3R,4S,6R)-4,6-diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-; KANAMYCIN B; Hexopyranoside, 4,6-diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-; kananmycin B; kdm; nebramycinfactor5; Bekanamycin; kanendomycin; (1S,2R,3R,4S,6R)-4,6-Diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside; nebramycinv

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 807.7±65.0 °C at 760 mmHg
• 熔点: 178-182° (dec)
• 分子式: C₁₈H₃₇N₅O₁₀
• 分子量: 483.514
• 闪点: 442.3±34.3 °C
• 精确质量: 483.254028
• PSA: 288.40000
• LogP: -2.93
• 蒸汽压: 0.0±6.5 mmHg at 25°C
• 折射率: 1.668
• 储存条件: 通风低温干燥

生物活性

• 描述: Bekanamycin是一种氨基糖苷类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  天然产物 >> 其他
  研究领域 >> 感染

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WK1975000 CHEMICAL NAME : D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6 -diamino-2,6-dideoxy- alpha-D-glucopyranosyl-(1-6))-2-deoxy- CAS REGISTRY NUMBER : 4696-76-8 BEILSTEIN REFERENCE NO. : 0061646 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H37-N5-O10 MOLECULAR WEIGHT : 483.60 WISWESSER LINE NOTATION : T6OTJ CZ DQ EQ F1Z BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DZ EQ F1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,159,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,159,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 132 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,677,1974

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