22457-89-2

• 常用中文名：苯磷硫胺
• 常用英文名：Benfotiamine
• CAS号：22457-89-2
• 分子式：C₁₉H₂₃N₄O₆PS
• 分子量：466.448
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-05-18 08:00:00
• 更新时间：2024-01-02 16:44:40
• Benfotiamine是维生素B1的衍生物,有抗氧化活性。

名称

• 中文名: 苯磷硫胺
• 英文名: benfotiamine
• 中文别名: S-苯甲酰基硫胺O-单磷酸酯
• 英文别名: berdi; S-benzoylthiamine monophosphate; bietamine; biotamin; S-[(2Z)-2-{[(4-Amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino}-5-(phosphonooxy)-2-penten-3-yl] benzenecarbothioate; betivina; S-Benzoyl-thiamin-monophosphat; EINECS 245-013-4; Benfotiamine; neurostop; S-Benzoylthiamine O-Monophosphate; 8088c.b.; Benfotiaminum; S-Benzoyl-thiamin-O-monophosphat; S-benzoylthiamine-O-monophosphate; MFCD00057343; MilgaMMa; btmp; benzenecarbothioic acid, S-[(1Z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester; nitanevril; tabiomyl

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 745.1±70.0 °C at 760 mmHg
• 熔点: 165ºC
• 分子式: C₁₉H₂₃N₄O₆PS
• 分子量: 466.448
• 闪点: 404.4±35.7 °C
• 精确质量: 466.107605
• PSA: 191.05000
• LogP: 1.81
• 外观性状: 闪光黑色粉末
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.645
• 储存条件: 2-8°C

生物活性

• 描述: Benfotiamine是维生素B1的衍生物,有抗氧化活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tarallo S, Beltramo E, Berrone E, Porta M. Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta Diabetol. 2012 Dec;49 Suppl 1:141-51.

  [2]. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway:Evidence from clinical studies. Diabetes Obes Metab. 2012 Dec 26.

  [3]. Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562.

  [4]. Hans-Peter Hammes, Xueliang Du, Diane Edelstein, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine, 2003, 9, 294 - 299

  [5]. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. International Journal of Clinical Pharmacology and Therapeutics, 1996, 34(2):47-50

  [6]. Benfotiamine

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DH6910000 CHEMICAL NAME : Benzoic acid, thio-, S-ester with N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro xy- 2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester) CAS REGISTRY NUMBER : 22457-89-2 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H23-N4-O6-P-S MOLECULAR WEIGHT : 466.49 WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1VMY1&UYSVR&2OPQQO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,781,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,78,1968

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: DH6910000