苯磷硫胺

• 常用名: 苯磷硫胺
• 英文名: Benfotiamine
• CAS号: 22457-89-2
• 分子量: 466.448
• 密度: 1.4±0.1 g/cm3
• 沸点: 745.1±70.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃N₄O₆PS
• 熔点: 165ºC
• 闪点: 404.4±35.7 °C

苯磷硫胺用途

Benfotiamine是维生素B1的衍生物，有抗氧化活性。

苯磷硫胺名称

• 中文名: 苯磷硫胺
• 英文名: benfotiamine
• 中文别名: S-苯甲酰基硫胺O-单磷酸酯

苯磷硫胺生物活性

• 描述: Benfotiamine是维生素B1的衍生物,有抗氧化活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tarallo S, Beltramo E, Berrone E, Porta M. Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta Diabetol. 2012 Dec;49 Suppl 1:141-51.

  [2]. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway:Evidence from clinical studies. Diabetes Obes Metab. 2012 Dec 26.

  [3]. Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562.

  [4]. Hans-Peter Hammes, Xueliang Du, Diane Edelstein, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine, 2003, 9, 294 - 299

  [5]. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. International Journal of Clinical Pharmacology and Therapeutics, 1996, 34(2):47-50

  [6]. Benfotiamine

苯磷硫胺物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 745.1±70.0 °C at 760 mmHg
• 熔点: 165ºC
• 分子式: C₁₉H₂₃N₄O₆PS
• 分子量: 466.448
• 闪点: 404.4±35.7 °C
• 精确质量: 466.107605
• PSA: 191.05000
• LogP: 1.81
• InChIKey: BTNNPSLJPBRMLZ-GHRIWEEISA-N
• SMILES: CC(=C(CCOP(=O)(O)O)SC(=O)c1ccccc1)N(C=O)Cc1cnc(C)nc1N
• 外观性状: 闪光黑色粉末
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.645
• 储存条件: 2-8°C

苯磷硫胺毒性和生态

苯磷硫胺安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: DH6910000

苯磷硫胺英文别名

• berdi
• S-benzoylthiamine monophosphate
• bietamine
• biotamin
• S-[(2Z)-2-{[(4-Amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino}-5-(phosphonooxy)-2-penten-3-yl] benzenecarbothioate
• betivina
• S-Benzoyl-thiamin-monophosphat
• EINECS 245-013-4
• Benfotiamine
• neurostop
• S-Benzoylthiamine O-Monophosphate
• 8088c.b.
• Benfotiaminum
• S-Benzoyl-thiamin-O-monophosphat
• S-benzoylthiamine-O-monophosphate
• MFCD00057343
• MilgaMMa
• btmp
• benzenecarbothioic acid, S-[(1Z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester
• nitanevril
• tabiomyl