3286-46-2

• 常用中文名：舒布硫胺
• 常用英文名：Sulbutiamine
• CAS号：3286-46-2
• 分子式：C₃₂H₄₆N₈O₆S₂
• 分子量：702.89
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-08-04 00:30:52
• 更新时间：2024-01-02 09:28:30
• Sulbutiamine 是一种高脂溶性的合成的维生素 B1 类似物,可用于无力症的研究。

名称

• 中文名: 硫锌酸硫胺
• 英文名: Sulbutiamine
• 中文别名: 舒布硫胺
• 英文别名: MFCD01726427; 2,2-dimethyl-6-[(E)-{4-[(E)-phenyldiazenyl]naphthalen-1-yl}diazenyl]-2,3-dihydro-1H-perimidine; Arcalion; Vitaverin; bisibutiamine; Fat Black HB; O-Isobutyroylthiamine disulfide; 2,2-Dimethyl-6-[(E)-{4-[(E)-phenyldiazenyl]-1-naphthyl}diazenyl]-2,3-dihydro-1H-perimidine; Disulfanediylbis(2Z)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-en-3,5-diylbis(2-methylpropanoat); SOLVENT BLACK 3; Vitaberin; O,O'-Diisobutyrylthiamine disulfide; Propanoic acid, 2-methyl-, dithiobis(3Z)-3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl ester; 1H-Perimidine, 2,3-dihydro-2,2-dimethyl-6-[(E)-2-[4-[(E)-2-phenyldiazenyl]-1-naphthalenyl]diazenyl]-; EINECS 221-937-3; Thiamine disulfide O,O-diisobutyrate; 2,3-dihydro-2,2-dimethyl-6-[[4-(phenylazo)-1-naphthyl]azo]perimidine; Ceres Black BN; Disulfanediylbis(2Z)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-ene-3,5-diyl bis(2-methylpropanoate); Sulbutiamine; Disulfanediylbis(2Z)-2-{[(4-amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino}-2-pentene-3,5-diyl bis(2-methylpropanoate)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 726.0±60.0 °C at 760 mmHg
• 熔点: 140.5-141.5 °C
• 分子式: C₃₂H₄₆N₈O₆S₂
• 分子量: 702.89
• 闪点: 392.9±32.9 °C
• PSA: 247.42000
• LogP: 7.51
• 外观性状: 白色至类白色粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.702
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Sulbutiamine 是一种高脂溶性的合成的维生素 B1 类似物,可用于无力症的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: Sulbutiamine对经受氧-葡萄糖剥夺的海马CA1锥体神经元显示出神经保护作用。 Sulbutiamine以浓度依赖性方式增强电生理特性,如兴奋性突触传递和内在神经元膜输入阻力[1]。 Sulbutiamine减弱由血清剥夺诱导的凋亡细胞死亡,并以剂量依赖性方式刺激GSH和GST活性。此外,sulbutiamine可降低切割的caspase-3和AIF的表达[2]。
• 参考文献:

  [1]. Kwag J, et al. Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. Biol Pharm Bull. 2011;34(11):1759-64.

  [2]. Kang KD, et al. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LQ2721000 CHEMICAL NAME : Formamide, N,N'-(dithiobis(2-(2-hydroxyethyl)-1-methylvinylene)) bis(N-((4-amino-2-met hyl-5- pyrimidinyl)methyl)-, diisobutyrate (ester) CAS REGISTRY NUMBER : 3286-46-2 BEILSTEIN REFERENCE NO. : 0741531 LAST UPDATED : 199712 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C32-H46-N8-O6-S2 MOLECULAR WEIGHT : 702.98 WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1NVHY1&UY2OVY1&1&SSY2OVY1&1&UY1&NVH1- ET6N CNJ B1 DZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

安全

• 危害码 (欧洲): Xi