舒布硫胺

• 常用名: 舒布硫胺
• 英文名: Sulbutiamine
• CAS号: 3286-46-2
• 分子量: 702.89
• 密度: 1.3±0.1 g/cm3
• 沸点: 726.0±60.0 °C at 760 mmHg
• 分子式: C₃₂H₄₆N₈O₆S₂
• 熔点: 140.5-141.5 °C
• 闪点: 392.9±32.9 °C

舒布硫胺用途

原料药促进成长；帮助消化，特别是碳水化合物的消化；改善精神状况；维持、肌肉、心脏活动的正常；减轻晕机、晕船；可缓解有关牙科手术后的痛苦。

舒布硫胺名称

• 中文名: 硫锌酸硫胺
• 英文名: Sulbutiamine
• 中文别名: 舒布硫胺

舒布硫胺生物活性

• 描述: Sulbutiamine 是一种高脂溶性的合成的维生素 B1 类似物,可用于无力症的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: Sulbutiamine对经受氧-葡萄糖剥夺的海马CA1锥体神经元显示出神经保护作用。 Sulbutiamine以浓度依赖性方式增强电生理特性,如兴奋性突触传递和内在神经元膜输入阻力[1]。 Sulbutiamine减弱由血清剥夺诱导的凋亡细胞死亡,并以剂量依赖性方式刺激GSH和GST活性。此外,sulbutiamine可降低切割的caspase-3和AIF的表达[2]。
• 参考文献:

  [1]. Kwag J, et al. Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. Biol Pharm Bull. 2011;34(11):1759-64.

  [2]. Kang KD, et al. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39.

舒布硫胺物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 726.0±60.0 °C at 760 mmHg
• 熔点: 140.5-141.5 °C
• 分子式: C₃₂H₄₆N₈O₆S₂
• 分子量: 702.89
• 闪点: 392.9±32.9 °C
• PSA: 247.42000
• LogP: 7.51
• InChIKey: CKHJPWQVLKHBIH-UHFFFAOYSA-N
• SMILES: CC(=C(CCOC(=O)C(C)C)SSC(CCOC(=O)C(C)C)=C(C)N(C=O)Cc1cnc(C)nc1N)N(C=O)Cc1cnc(C)nc1N
• 外观性状: 白色至类白色粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.702
• 储存条件: 库房通风低温干燥

舒布硫胺毒性和生态

舒布硫胺安全信息

• 危害码 (欧洲): Xi

舒布硫胺靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：S16 Schwann cell PMP22 intronic element firefly luciferase assay 来源：NCGC 靶标：peripheral myelin protein 22 [Rattus norvegicus] External Id：cmt-p4-fluc-fda_regid

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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舒布硫胺英文别名

• MFCD01726427
• 2,2-dimethyl-6-[(E)-{4-[(E)-phenyldiazenyl]naphthalen-1-yl}diazenyl]-2,3-dihydro-1H-perimidine
• Arcalion
• Vitaverin
• bisibutiamine
• Fat Black HB
• O-Isobutyroylthiamine disulfide
• 2,2-Dimethyl-6-[(E)-{4-[(E)-phenyldiazenyl]-1-naphthyl}diazenyl]-2,3-dihydro-1H-perimidine
• Disulfanediylbis(2Z)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-en-3,5-diylbis(2-methylpropanoat)
• SOLVENT BLACK 3
• Vitaberin
• O,O'-Diisobutyrylthiamine disulfide
• Propanoic acid, 2-methyl-, dithiobis(3Z)-3-[1-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethylidene]-3,1-propanediyl ester
• EINECS 221-937-3
• Thiamine disulfide O,O-diisobutyrate
• 2,3-dihydro-2,2-dimethyl-6-[[4-(phenylazo)-1-naphthyl]azo]perimidine
• Ceres Black BN
• Disulfanediylbis(2Z)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-ene-3,5-diyl bis(2-methylpropanoate)
• Sulbutiamine
• Disulfanediylbis(2Z)-2-{[(4-amino-2-methyl-5-pyrimidinyl)methyl](formyl)amino}-2-pentene-3,5-diyl bis(2-methylpropanoate)