519032-08-7

• 常用中文名：2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯
• 常用英文名：Methyl 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate
• CAS号：519032-08-7
• 分子式：C₁₇H₁₉N₃O₆
• 分子量：361.349
• 发布时间：2018-07-24 22:08:37
• 更新时间：2026-07-07 11:57:43

名称

• 中文名: 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯
• 英文名: methyl 5-hydroxy-4-oxo-2-[2-(phenylmethoxycarbonylamino)propan-2-yl]-1H-pyrimidine-6-carboxylate
• 中文别名: 6-二氢嘧啶-4-甲酸甲酯; 拉替拉韦杂质15; 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯(雷特格韦中间体); 雷特格韦中间体N-4; 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯(拉替拉韦中三); 甲基 2-(2-(((苄氧基)羰基)氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-羧酸酯; 拉替拉韦中间体三; 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯(中三); 雷特格韦-RT5; 雷特格韦中间体E; 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1,6-二氢嘧啶-4-甲酸甲酯(雷特格韦中间体片段-2); 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代-1; 甲基嘧啶中三; 中三; 雷特格韦中间体D; 2-(2-(苄氧基羰基氨基)丙-2-基)-5-羟基-6-氧代一1,6-二氢嘧啶-4-甲酸甲酯(雷特格韦); 拉替拉韦钾中三
• 英文别名: methyl 5-hydroxy-4-oxo-2-[2-(phenylmethoxycbonylamino)propan-2-yl]-1H-pyrimidine-6-cboxylate; InterMediate E of Ralteavir; 4-Pyrimidinecarboxylic acid, 1,6-dihydro-5-hydroxy-2-[1-methyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-6-oxo-, methyl ester; Methyl 2-(2-(benzyloxycbonyl)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyriMidine-4-cboxylate; methyl 1,4-dioxaspiro[4.5]decane-8-acetate; Methyl 2-(2-(benzyloxycbonylamino; methyl 2-[1-[[(benzyloxy)carbonyl]amino]-1-methylethyl]-5,6; 7 - (benzyloxy) - 3,4,12,12a-tetrahydro-1h - [1,4] oxazine [3,4-c] pyrido [2,1-f] [1,2,4] triazine-6,8 Dione; Methyl2-(2-(benzyloxycarbonylamino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate; 2-(2-(BenzyloxycbonylaMino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyriMidine-4-Methyl forMate; (1,4-dioxa-spiro[4.5]dec-8-yl)-acetic acid methyl ester; methyl 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5,6-dihydroxypyrimidine-4-carboxylate; Methyl 2-(2-{[(benzyloxy)carbonyl]amino}-2-propanyl)-5-hydroxy-6-oxo-1,6-dihydro-4-pyrimidinecarboxylate; 1,6-Dihydro-5-hydroxy-2-[1-methyl-1-[[benzylcbamoyl]amino]ethyl]-6-oxo-4-pyrimidinecboxylic Acid; 2-Piperidinecboxylicacid,methylester,(2R)-,hydrochloride(1:4); Methyl-2-(2-{[(benzyloxy)cbo; Lincomycin Impurity 4Hydrochloride(Lincomycin Impurity CHydrochloride); Methyl 2-(2-{[(benzyloxy)carbonyl]amino}propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate; Methyl 2-(2-{[(benzyloxy)carbonyl]amino}propan-2-yl)-5,6-dihydroxypyrimidine-4-cboxylate; Methyl 2-(2-(benzyloxycbonylamino)propan-2-yl)-5-hydroxy-6-oxo-l,6-dihydropyrimidine-4-cboxylate(Ralteavir); Methyl-2-(2-{[(benzyloxy)carbonyl]amino}propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidin-4-carboxylat; 4-PYRIMIDINECBOXYLIC ACID, 1,6-DIHYDRO-5-HYDROXY-2-[1-METHYL-1-[[(PHENYLMETHOXY)carbonyl]AMINO]ETHYL]-6-OXO-, METHYL ESTER; 6-dihydropyrimidine-4-cboxylate; Methyl2-(2-(benzyloxycbonylamino)propan-2-yl)-5-hydroxy-6-oxo-1; 1,6-Dihydro-5-hydroxy-2-[1-methyl-1-[[benzylcbamoyl]amino]ethyl]-6-oxo-4-pyrimidinecboxylic Acid Methyl Ester; methyl 2-(1-{[(benzyloxy) carbonyl] amino}-1-methylethyl)-5,6-dihydroxypyrimidine-4-carboxylate; Methyl 2-(2-(benzyloxycbonylamino)propan-2-yl)-5-hydroxy-6-oxo-l,6-dihydropyrimidine-4-cboxylate; LTGW-3; Methyl 2-(2-(benzyloxycbonylamino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-cb; Methyl 2-(2-(benzyloxycbonylamino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-cboxylate; (benzyloxycbonylaMino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyriMidine-4-cboxylate; Methyl2-(1-{[(benzyloxy)carbonyl]amino}-1-Methylethyl)-5,6-dihydroxypyriMidine-4-cboxyllate; methyl 2-(1,4-dioxaspiro[4.5]dec-8-yl)acetate; 2-(2-((Benzyloxycbonyl)amino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4（UncleStructure）; METHYL 2-(2-(BENZYLOXYCBONYLAMINO)PROPAN-2-YL)-5-HYDROXY-6-OXO-1,6-DIHYDROPYRIMIDINE-4-CBOXYLATE 519-7; 2 - (2 - {[((benzyl oxygen) carbonyl] amino} c - 2 - base) - 5 - hydroxy - 6 - oxygen generation - 1, 6 - dihydro pyrimidine - 4 - cboxylic acid methyl ester; Methyl 2-[1-[[(benzyloxy)carbonyl]amino]-1-Methylethyl]-5,6-dihydroxypyriMidine-4-cboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 552.6ºC at 760 mmHg
• 分子式: C₁₇H₁₉N₃O₆
• 分子量: 361.349
• 闪点: 288ºC
• 精确质量: 361.127380
• PSA: 130.61000
• LogP: 1.06
• 外观性状: 棕色固体
• 折射率: 1.595
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933599090

合成路线

518047-98-8 762-42-5 ~56% 519032-08-7

文献：Guo, Di-Liang; Zhang, Xing-Jie; Wang, Rui-Rui; Zhou, Yu; Li, Zeng; Xu, Jin-Yi; Chen, Kai-Xian; Zheng, Yong-Tang; Liu, Hong Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7114 - 7118

100134-82-5 ~% 519032-08-7

文献：Guo, Di-Liang; Zhang, Xing-Jie; Wang, Rui-Rui; Zhou, Yu; Li, Zeng; Xu, Jin-Yi; Chen, Kai-Xian; Zheng, Yong-Tang; Liu, Hong Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7114 - 7118

501-53-1 ~% 519032-08-7

文献：Pace, Paola; Di Francesco, M. Emilia; Gardelli, Cristina; Harper, Steven; Muraglia, Ester; Nizi, Emanuela; Orvieto, Federica; Petrocchi, Alessia; Poma, Marco; Rowley, Michael; Scarpelli, Rita; Laufer, Ralph; Paz, Odalys Gonzalez; Monteagudo, Edith; Bonelli, Fabio; Hazuda, Daria; Stillmock, Kara A.; Summa, Vincenzo Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2225 - 2239

1064707-10-3 ~% 519032-08-7

文献：Summa, Vincenzo; Petrocchi, Alessia; Bonelli, Fabio; Crescenzi, Benedetta; Donghi, Monica; Ferrara, Marco; Fiore, Fabrizio; Gardelli, Cristina; Paz, Odalys Gonzalez; Hazuda, Daria J.; Jones, Philip; Kinzel, Olaf; Laufer, Ralph; Monteagudo, Edith; Muraglia, Ester; Nizi, Emanuela; Orvieto, Federica; Pace, Paola; Pescatore, Giovanna; Scarpelli, Rita; Stillmock, Kara; Witmer, Marc V.; Rowley, Michael Journal of Medicinal Chemistry, 2008 , vol. 51, # 18 p. 5843 - 5855

518047-98-8 ~% 519032-08-7

文献：Pace, Paola; Di Francesco, M. Emilia; Gardelli, Cristina; Harper, Steven; Muraglia, Ester; Nizi, Emanuela; Orvieto, Federica; Petrocchi, Alessia; Poma, Marco; Rowley, Michael; Scarpelli, Rita; Laufer, Ralph; Paz, Odalys Gonzalez; Monteagudo, Edith; Bonelli, Fabio; Hazuda, Daria; Stillmock, Kara A.; Summa, Vincenzo Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2225 - 2239

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%