81058-27-7

• 常用中文名：2,3,4,6-O-四特戊酰基-alpha-D-溴代吡喃葡萄糖
• 常用英文名：Tetra-o-pivaloyl-alpha-D-glucopyranosyl bromide
• CAS号：81058-27-7
• 分子式：C₂₆H₄₃BrO₉
• 分子量：579.518
• 相关类别： 生物化工 糖类化合物 单糖
• 发布时间：2018-12-31 19:20:57
• 更新时间：2026-07-16 22:11:51

名称

• 中文名: 2,3,4,6-O-四特戊酰基-alpha-D-溴代吡喃葡萄糖
• 英文名: 2,3,4,6-TETRA-O-PIVALOYL-α-D-GLUCOPYRANOSYL BROMIDE
• 中文别名: 5-氯-2.3.3-三甲基吲哚; 2,3,4,6-四邻叔戊酰基-ALPHA-D-溴化吡喃葡萄糖; 2,3,4,6-四邻叔戊酰基-alpha-d-溴化吡喃葡萄糖; 2,3,4,6-O-四特戊酰基-ALPHA-D-溴; 2,3,4,6-四-O-新戊酰基-Α-D-吡喃葡萄糖基溴化物; 2,3,4,6-O-四特戊酰基-ALPHA-D-溴代吡喃葡萄糖; EMPAGLIFLOZIN杂质35; (2R,3R,4S,5R,6R)-2-溴-6-(((新戊酰氧基)甲基)四氢-2H-吡喃-3,4,5-三基三(2,2-二甲基丙酸酯)(恩格列净杂质); 2.3.-四特戊酰基ALPHA-D-溴代吡喃萄萄糖; 2.3.-四特戊酰基ALPHA-D~溴代吡喳葡萄糖; 2,3,4,6-四-氧-特戊酰基-Α-D-溴代吡喃葡萄糖; 2,3,4,6-O-四新戊基- ALPHA-D-溴代葡萄糖; 依帕列净杂质35; 化合物 (2R,3R,4S,5R,6R)-2-BROMO-6-((PIVALOYLOXY)METHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIYL TRIS(2,2-DIMETHYLPROPANOATE); 2,3,4,6-O-四特戊酰基-ALPHA-D-溴代吡喃葡萄糖,依帕列净中间体; 2,3,4,6-四-O-新戊酰基-Α-D-吡喃葡糖基溴化物; 依帕列净杂质66; 2,3,4,6-O-四特戊酰基-Α-D-溴代吡喃葡萄糖; 2,3,4,5-O-四特戊酰基-ALPHA-D-溴代吡喃葡萄糖; 溴吡喃葡萄糖Piv; 卡格列净 中间体 KG-2.1; (2R,3R,4S,5R,6R)-2-溴-6-((新戊酰氧基)甲基)四氢-2H-吡喃-3,4,5-三基三(2,2-二甲基丙酸酯)
• 英文别名: (2R,3R,4S,5R,6R)-2-BroMo-6-((pivaloyloxy)Methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-diMethylpropanoate); Canagliflozin Intermediate3; 2,3,4,6-Tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide (Related Reference); per-O-pivaloyl-±-D-glucopyranosyl bromide; T6OTJ BE COVX1&1&1 DOVX1&1&1 EOVX1&1&1 F1OVX1&1&1 &&α-D-Gluco Form; Empagliflozin Impurity 66; α-D-Glucopyranosyl bromide, 2,3,4,6-tetrakis(2,2-dimethylpropanoate); 2,3,3-TRIMETHYL-5-CHLORO-3H-INDOLE; 2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide; (2R,3R,4S,5R,6R)-2-Bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimet; TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE; (2R,3R,4S,5R,6R)-2-Bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate) (Empagliflozin Impurity）; 2S,3S,4S,5R,6S)-6-bromo-3,4,5-tris(2,2-dimethylpropanoyloxy)tetrahydropyran-2-yl]methyl 2,2-dimethyl; Tetra-O-pivaloyl-α-D-glucopyranosyl Bromide; 2,3,4,6-Tetra-O-pivaloyl-α- D -glucopyranosyl bromide; [(2S,3S,4S,5R,6S)-6-bromo-3,4,5-tris(2,2-dimethylpropanoylox; TETRAKIS(2,2-DIMETHYLPROPANOATE)-A-D-GLUCOPYRANOSYL BROMIDE; 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE; EOS-61173; 4. 2,3,4,6-Tetra-O-pivaloyl-alpha-D-glucopyranosyl broMide; 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL; 2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl bromide; 2,3,4,6-Tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide; 2,3,4,6-Tetra-O-pivaloyl-a-D-glucopytanosyl bromide; α-D-glucopyranosyl bromide, 2,3,4,6-tetra-O-pivaloyl; [(2R,3R,4S,5R,6R)-6-bromo-3,4,5-tris[(2,2-dimethylpropanoyl)oxy]oxan-2-yl]methyl 2,2-dimethylpropanoate; 2, 3, 4, -tetrapentanoyl-a-D-Bromopyran glucose; 2,3,4,6-Tetra-O-pivaloyl-a-D-glucopyranosyl bromide (stabilised with CaCO3); 2,3,4,6-Tetra-O-pivaloyl-α-D-glucopytanosyl bromide; [(2S,3S,4S,5R,6S)-6-broMo-3,4,5-tris(2,2-diMethylpropanoyloxy)tetrahydropyran-2-yl]Methyl2,2-diMethylpropanoate; 2,3,4,6-Tetra-O-pivaloyl-Alpha-D-Glucopyranosyl bromide; 2,3,4,6-Tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide >= (TLC); 2,3,4,5-O-tetratervaloyl-ALPHA-D-bromopyranoglucose; α-D-Glucopyranosyl bromide, tetrakis(2,2-dimethylpropanoate); 2,3,4,6-Tetra-O-Pivaloyl-α-D-Glucopyranosyl Bromide; 2,3,4,6-Tetra-O-pivaloyl-a-D-glucopyranosylbromide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 530.5±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₃BrO₉
• 分子量: 579.518
• 闪点: 274.6±30.1 °C
• 精确质量: 578.209045
• PSA: 114.43000
• LogP: 6.96
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.494
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36

合成路线

1213234-53-7 ~% 81058-27-7

文献：US2011/87017 A1, ; Page/Page column 34 ;

81058-26-6 ~98% 81058-27-7

文献：Presser, Armin; Kunert, Olaf; Poetschger, Irmgard Monatshefte fur Chemie, 2006 , vol. 137, # 3 p. 365 - 374

3282-30-2 ~% 81058-27-7

文献：Monatshefte fur Chemie, , vol. 137, # 3 p. 365 - 374

492-62-6 ~% 81058-27-7

文献：WO2012/140120 A1, ; WO 2012/140120 A1

114179-84-9 ~% 81058-27-7

文献：Synlett, , # 16 p. 2609 - 2612

上下游产品

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