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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：Teleocidin A1
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Teleocidin A1
纯度：98.0%
规格：5mg/1mg/1g/1g
联系人：李先生
联系电话：18916172912

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70497-14-2生产厂家

70497-14-2价格

70497-14-2

70497-14-2结构式

常用中文名：鞘丝藻毒素 a
常用英文名：Teleocidin A1
CAS号：70497-14-2
分子式：C₂₇H₃₉N₃O₂
分子量：437.61700
相关类别：信号通路表观遗传学 PKC
发布时间：2018-04-17 08:00:00
更新时间：2024-01-03 07:11:25
Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。

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中文名	鞘丝藻毒素 a
英文名	lyngbyatoxin a
英文别名	lyngbyatoxin 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl) (2S,5S)-9-[(R)-1-Ethenyl-1,5-dimethyl-4-hexenyl]-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-9-(1-etheny teleocidina Teleocicin A-1 lyngbyatoxin A (teleocidin A-1) 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl) 5-dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-l teleocidin A1

描述	Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。
相关类别	信号通路 >> 表观遗传学 >> PKC 研究领域 >> 癌症信号通路 >> TGF-beta/Smad 信号通路 >> PKC
参考文献	[1]. Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A). Food Chem Toxicol. 1992;30(9):795-801. [2]. Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29(8):703-709.

密度	1.06 g/cm3
沸点	665.1ºC at 760 mmHg
分子式	C₂₇H₃₉N₃O₂
分子量	437.61700
闪点	356ºC
精确质量	437.30400
PSA	68.36000
LogP	5.24580

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WY1981000

CHEMICAL NAME :: 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-9-(1-ethenyl-1,5- dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-m ethylethyl)-

CAS REGISTRY NUMBER :: 70497-14-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H39-N3-O2

MOLECULAR WEIGHT :: 437.69

WISWESSER LINE NOTATION :: T569 1A O DM JN LVM&&TJ FX1&1U1&3UY1&1 J1 KY1&1 N1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,636,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 204,193,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 26,660,1962