217082-60-5

• 常用中文名：[Pyr1]-爱帕琳肽-13
• 常用英文名：[Pyr1] -Apelin 13
• CAS号：217082-60-5
• 分子式：C₆₉H₁₀₈N₂₂O₁₆S
• 分子量：1533.8
• 相关类别： 生物化工 多肽
• 发布时间：2018-08-05 20:30:26
• 更新时间：2026-07-23 17:23:57
• [Pyr1]-Apelin-13 是一种高效的,选择性的内源性 apelin 受体激动剂。

名称

• 中文名: 人牛吡啶Apelin-13
• 英文名: [Pyr1]-Apelin-13
• 中文别名: [Pyr1]-Apelin-13-[Pyr1]-爱帕琳肽-13; 3-二甲基尿酸; PYR1]-爱帕琳肽-13醋酸盐; [PYR1]-APELIN 13,ENDOGENOUS APELIN RECTOR (APJ)激动剂; [PYR1]-爱帕琳肽-13; (GLP1)-APELIN-13(人,牛); 人牛吡啶APELIN-13; 焦谷氨酸1]-Apelin-13; (S)-2-((S)-1-((S)-2-((S)-1-((6S,9S,12S,15S,18S)-15-((1H-咪唑-4-基)甲基)-1-氨基-18-(4-氨基丁基)-6-((S)-1-((S)-5-胍基-2-((S)-5-氧代吡咯烷-2-甲酰氨基)戊酰基)吡咯烷-2-甲酰氨基)-12-(羟甲基)-1-亚氨基-9-异丁基7,10,13,16,19-五氧代-2,8,11,14,17,20-六氮杂二十二烷-22-酰基)吡咯烷-2-甲酰氨基)-4-(甲硫基)丁酰基)吡咯烷-2-甲酰氨基)-3-苯基丙酸; PYR1] -APELIN-13 三氟乙酸盐; 人,牛(GLP1)-APELIN-13肽; 人牛吡啶APELIN-13 Solbio/索莱宝 IP1170
• 英文别名: pQRPRLSHKGPMPF; [PYR1]-APELIN-13; [Pyr1]-Apelin-13,XRPRLSHKGPMPF,[pGlu1]-Apelin-13; 3-Dimethyluric acid; PYR-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH //BP; Deltorphin I; (GLP1)-APELIN-13, HUMAN, BOVINE; GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; [PGLU1]APELIN , HUMAN, BOVINE; (PYR1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT); {Glp}-RPRLSHKGPMPF; [Pyr1]-Apelin 13, endogenous apelin rector (APJ) agonist; (Glp1)-Apelin-13; [PE]APELIN-13, HUMAN, BOVINE; PYR-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; GLP-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; GLP-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE: PRLSHKGPMPF; (Pyr)-Apelin-13 (human, bovine, mouse, rat) acetate salt; PYR-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH; PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; L-Phenylalanine, 5-oxo-L-prolyl-L-ginyl-L-prolyl-L-ginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl; Pyr-apelin-13; 5-Oxo-L-prolyl-L-ginyl-L-prolyl-L-ginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; pyroglutamyl apelin-13; PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; PGLU-G-PRO-G-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; [pGlu1]-Apelin-13; PYR-RPRLSHKGPMPF-OH; [Pyr1]-Apelin-13 trifluoroacetate salt; 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; (PYR1)-APELIN-13 (HUMAN, BOVINE)

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₆₉H₁₀₈N₂₂O₁₆S
• 分子量: 1533.8
• 精确质量: 1532.80343662
• PSA: 613.26000
• LogP: -3.42
• 折射率: 1.696
• 储存条件:

  保存方法： -15 °C

生物活性

• 描述: [Pyr1]-Apelin-13 是一种高效的,选择性的内源性 apelin 受体激动剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  多肽产品
  研究领域 >> 心血管疾病
• 体外研究: [pyr1] -apelin-13在lipoPEG颗粒(lipoPEG-PA13)中的包封导致在生理条件下持续和延长的药物释放[1]。
• 体内研究: [Pyr1] -apelin-13纳米载体在压力超负荷诱导的心力衰竭小鼠模型中显示[Pyr1] -apelin-13在预防心脏功能障碍中的可持续长期作用[1]。 [Pyr1] apelin-13(1,5μg)可改善大鼠的运动活动并减轻疼痛症状,腔大小和caspase-3水平。 [Pyr1] apelin-13(1,5μg)显着增加热爪退缩潜伏期。与来自SCI后第2周的SCI动物相比,5μg剂量的[Pyr1] apelin-13也在缩爪阈值中产生显着的减弱[2]。
• 参考文献:

  [1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.

  [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.

合成路线

29022-11-5 35661-60-0 71989-31-6 35661-40-6 71989-28-1 详细

文献：Zhang, Yanyan; Maitra, Rangan; Harris, Danni L.; Dhungana, Suraj; Snyder, Rodney; Runyon, Scott P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2992 - 2997

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