217082-60-5

217082-60-5 structure

217082-60-5 structure

Name: [Pyr1] -Apelin 13
Chemical Name: [Pyr1]-Apelin-13
CAS Number: 217082-60-5
Molecular Formula: C₇₀H₁₀₉N₂₁O₁₆S
Molecular Weight: 1532.81
Catalog: Biochemical Peptide
Create Date: 2018-08-05 20:30:26
Modify Date: 2024-01-02 18:33:46
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

Name	[Pyr1]-Apelin-13
Synonyms	PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE pQRPRLSHKGPMPF Deltorphin I PYR-RPRLSHKGPMPF-OH GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine L-Phenylalanine, 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE pyroglutamyl apelin-13

Description	[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cardiovascular Disease
In Vitro	[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].
In Vivo	[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].
References	[1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98. [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.

Density	1.5±0.1 g/cm3
Molecular Formula	C₇₀H₁₀₉N₂₁O₁₆S
Molecular Weight	1532.81
PSA	613.26000
LogP	-3.42
Index of Refraction	1.696
Storage condition	-15°C

29022-11-5 structure

29022-11-5

35661-60-0 structure

35661-60-0

71989-31-6 structure

71989-31-6

35661-40-6 structure

35661-40-6

71989-28-1 structure

71989-28-1

Detail

Literature: Zhang, Yanyan; Maitra, Rangan; Harris, Danni L.; Dhungana, Suraj; Snyder, Rodney; Runyon, Scott P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2992 - 2997

Precursor 7
29022-11-5 35661-60-0 71989-31-6 35661-40-6
71989-28-1 116611-64-4 98-79-3
DownStream 0